Results 151 to 160 of about 28,257 (295)
Advanced Science, EarlyView.TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin +11 more
wiley +1 more source
Forms of Influencing Young People through Media Discourse
EIRP Proceedings, 2018 In the modern age, conquered by the phenomena of globalization, mass media have become more and more significant for the lives of individuals who are building their horizons of representation under different influences, both internal and external.
Oana Drăgănescu
doaj
New arenas and approaches in agenda setting
, 2017 1st International Conference on New Trends in CommunicationKuramsal kökenleri Walter Lippmann ve Bernard Cohen’ in çalışmalarına dayanan gündem belirlemenin geleneksel modeli, medyanın kamu üzerindeki etkilerine odaklanır.
Gülnar, Mehmet
core
Advanced Science, EarlyView.This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai +9 more
wiley +1 more source
Migraciones, 2014 La presente investigación se ha centrado en analizar el posicionamiento de la prensa nacional con respecto a la inmigración. Se han analizado 819 noticias que tenían como protagonistas a inmigrantes o la inmigración, publicadas en El País, El Mundo, ABC ...
Juan José Igartua +2 more
doaj
Advanced Science, EarlyView.A physics‐informed property‐bridging framework links high‐throughput hardness screening to tensile performance in quenching and partitioning steels. By transferring metallurgically guided representations across properties, a single alloy composition is designed to achieve multiple strength grades through heat‐treatment tuning alone, offering a ...
Xiaolu Wei +7 more
wiley +1 more source
Agenda-Setting in the Regulatory State: Theory and Evidence
, 2016 Government officials who run administrative agencies must make countless decisions every day about what issues and work to prioritize. These agenda-setting decisions hold enormous implications for the shape of law and public policy, but they have ...
Coglianese, Cary, Walters, Daniel E.
core +1 more source
A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance
Advanced Science, EarlyView.A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang +9 more
wiley +1 more source
Advanced Science, EarlyView.SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang +8 more
wiley +1 more source
Inhibitory Decay and Supercritical Brain Dynamics During Sleep Deprivation
Advanced Science, EarlyView.Sleep deprivation progressively shifts human brain dynamics from near‐critical toward supercritical states, as revealed by neuronal avalanche analysis of resting‐state fMRI. These changes track subjective sleep pressure rather than vigilance lapses and show marked network heterogeneity. A circuit model suggests that reduced inhibitory efficacy provides
Dai Zhang +6 more
wiley +1 more source