Results 131 to 140 of about 777,631 (313)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Towards balancing efficiency and customer satisfaction in airplane boarding: An agent-based approach
Operations Research PerspectivesThe airplane boarding process, which can have a significant impact on a flight’s turnaround time, is often viewed by researchers and airlines primarily in terms of minimizing total boarding time (TBT).
Bruna H.P. Fabrin +3 more
doaj +1 more source
Investigating biocomplexity through the agent-based paradigm.
, 2015 Capturing the dynamism that pervades biological systems requires a computational approach that can accommodate both the continuous features of the system environment as well as the flexible and heterogeneous nature of component interactions.
Ventikos, Y, Kaul, H
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Dynamic scene modeling in agent-based survival simulation
Agent-based models (ABMs) simulate agents and the interactions between agents and their environments. We focus on the coevolution of prey and predator ABM.
Wall, Riley
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Dynamic Agent Compression [PDF]
We introduce a new method for processing agents in agent-based models that significantly improves the efficiency of certain models. Dynamic Agent Compression allows agents to shift in and out of a compressed state based on their changing levels of ...
Catherine Dibble, Stephen Wendel
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Agent-Oriented Modelling and Simulation for Robotic Based Predator Control
JOIV: International Journal on Informatics VisualizationAgent-oriented modeling (AOM) is a methodology that can develop complex tasks that involve multi-agent system development, such as robotic systems. There are still insufficient studies on how Agent-Oriented Modelling benefits robotic development.
Yee Wee Chieh Andy +3 more
doaj +1 more source
Agent-Based Urban Land Markets: Agent\'s Pricing Behavior, Land Prices and Urban Land Use Change [PDF]
We present a new bilateral agent-based land market model, which moves beyond previous work by explicitly modeling behavioral drivers of land-market transactions on both the buyer and seller side; formation of bid prices (of buyers) and ask prices (of ...
Tatiana Filatova +2 more
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