Results 141 to 150 of about 605,883 (210)

Optimal control of agent-based models via surrogate modeling. [PDF]

PLoS Comput Biol
Fonseca LL, Böttcher L, Mehrad B, Laubenbacher RC.   +3 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Enhancing Agent-Based Models with Real-Time Movement Data to Assess Impacts of Biosecurity Interventions on Disease Exposure in Healthcare Settings. [PDF]

ACM BCB
Thota RC, Uddin MYS, Bani-Yaghoub M, Abourraja MN, Sutkin G, Paschal S.   +5 more
europepmc   +1 more source

Mapping CAR T-Cell Design Space Using Agent-Based Models. [PDF]

Front Mol Biosci, 2022
Prybutok AN, Yu JS, Leonard JN, Bagheri N.   +3 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Synthetic population generation with public health characteristics for spatial agent-based models. [PDF]

PLoS Comput Biol
Von Hoene E, Roess A, Kavak H, Anderson T.   +3 more
europepmc   +1 more source

Agent Based Models of Polymicrobial Biofilms and the Microbiome-A Review. [PDF]

Microorganisms, 2021
Koshy-Chenthittayil S, Archambault L, Senthilkumar D, Laubenbacher R, Mendes P, Dongari-Bagtzoglou A.   +5 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Integrating agent-based models and clustering methods for improving image segmentation. [PDF]

Heliyon
Cuevas E, García-De-Lira SJ, Ascencio-Piña CR, Pérez-Cisneros M, Vega S.   +4 more
europepmc   +1 more source

Implementing a global approach for efficiently simulating molecular dynamics in agent-based models of biological tissue. [PDF]

STAR Protoc, 2022
Bergman D, Jackson TL.
europepmc   +1 more source