Results 181 to 190 of about 11,094,605 (304)

Importance of interindividual interactions in eco-evolutionary population dynamics: The rise of demo-genetic agent-based models. [PDF]

Evol Appl, 2022
Lamarins A, Fririon V, Folio D, Vernier C, Daupagne L, Labonne J, Buoro M, Lefèvre F, Piou C, Oddou-Muratorio S.   +9 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Leveraging agent-based models and deep reinforcement learning to predict taxis in cell migration. [PDF]

NPJ Syst Biol Appl
Camacho-Gomez D, Sentiero R, Ventre M, Garcia-Aznar JM.   +3 more
europepmc   +1 more source

Agent-based models of human response to natural hazards: systematic review of tsunami evacuation. [PDF]

Nat Hazards (Dordr), 2023
Mls K, Kořínek M, Štekerová K, Tučník P, Bureš V, Čech P, Husáková M, Mikulecký P, Nacházel T, Ponce D, Zanker M, Babič F, Triantafyllou I.   +12 more
europepmc   +1 more source

Agent-based models of the labor market

, 2018
M. Neugart, Matteo G. Richiardi
semanticscholar   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Surrogate modeling of Cellular-Potts agent-based models as a segmentation task using the U-Net neural network architecture. [PDF]

PLoS Comput Biol
Comlekoglu T, Toledo-Marín JQ, Comlekoglu T, DeSimone DW, Peirce SM, Fox G, Glazier JA.   +6 more
europepmc   +1 more source

Estimation of financial agent-based models with simulated maximum likelihood

, 2017
J. Kukacka, Jozef Baruník
semanticscholar   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

An analysis of spatial and temporal uncertainty propagation in agent-based models. [PDF]

Philos Trans A Math Phys Eng Sci
Gamal Y, Heppenstall A, Strachan W, Colasanti R, Zia K.   +4 more
europepmc   +1 more source