Results 211 to 220 of about 11,094,605 (304)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Incorporating social determinants of health into agent-based models of HIV transmission: methodological challenges and future directions. [PDF]

Front Epidemiol
Hotton AL, Nascimento de Lima P, Fadikar A, Collier NT, Khanna AS, Motley DN, Tatara E, Rimer S, Almirol E, Pollack HA, Schneider JA, Lempert RJ, Ozik J.   +12 more
europepmc   +1 more source

Model verification tools: a computational framework for verification assessment of mechanistic agent-based models. [PDF]

BMC Bioinformatics, 2022
Russo G, Parasiliti Palumbo GA, Pennisi M, Pappalardo F.   +3 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Inferring the relative importance of navigation and landscape effects for migratory populations using agent-based models. [PDF]

Ecol Modell
Kendzel MJ, de Roode JC, Waller LA.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

ISiCell: involving biologists in the design process of agent-based models in cell biology

, 2023
Cogoni F, Bernard D, Kazhen R, Valitutti S, Lobjois V, Cussat-Blanc S.   +5 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Task-oriented machine learning surrogates for tipping points of agent-based models. [PDF]

Nat Commun
Fabiani G, Evangelou N, Cui T, Bello-Rivas JM, Martin-Linares CP, Siettos C, Kevrekidis IG.   +6 more
europepmc   +1 more source

Agent-Based Models of Organizations [PDF]

Joseph E Harrington Jr, Myong-Hun Chang
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