Results 41 to 50 of about 24,645,095 (247)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Software Development Process Simulation: Multi Agent-Based Simulation versus System Dynamics [PDF]

, 2010
We present one of the first actual applications of Multi Agent-Based Simulation (MABS) to the field of software process simulation modelling (SPSM). Although there are some recent attempts to do this, we argue that these fail to take full advantage
Redha Cherif, Davidsson, Paul,, Cherif, Redha, Paul Davidsson, Davidsson, Paul   +4 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Agent-Based Simulation Of Crowd At The Tawaf Area. [PDF]

, 2007
Every year during the Hajj season there is a concentration of more than two million people within the vicinity of the Masjid Al-Haram. Congested areas, such as the tawaf,, may reach beyond a safe level of four people per square meter during this peak ...
Haron, F., Talib, Abdullah Zawawi, Sarmady, S.   +2 more
core   +1 more source

Agent-based guitar performance simulation [PDF]

Journal of the Brazilian Computer Society, 2008
Abstract The goal of this paper is to describe a systemaided performance and composition tool that aims to expand guitarist capacities by providing innovative ways in which the user can interact with the system. In order to achieve that, we decided to use an agentbased approach, independently modeling the active elements involved in a guitar ...
Leandro Costalonga, Rosa María Vicari, Evandro Manara Miletto   +2 more
openaire   +5 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Agent-Based Simulation of Ecological Models

, 2004
Coastal lagoons ecosystems are very complex to model and its global behaviour its hard to simulate. This com-plexity is even greater if the simulation model includes the intelligent entities like decision-makers involved in the system. Typical ecological
António Pereira, Luís Paulo Reis, Pedro Duarte   +2 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Going beyond BDI for agent-based simulation

Journal of Information and Telecommunication, 2019
Research in multi-agent systems has resulted in agent programming languages and logics that are used as a foundation for engineering multi-agent systems.
John Bruntse Larsen
doaj   +1 more source