Results 211 to 220 of about 9,278,000 (361)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

AI-supported clinical decision-making: in silico simulation of physician-AI interactions. [PDF]

Front Digit Health
Hofmann A.
europepmc   +1 more source

Novel sulfamethoxazole and 1-(2-fluorophenyl) piperazine derivatives as potential apoptotic and antiproliferative agents by inhibition of BCL2; design, synthesis, biological evaluation, and docking studies [PDF]

Nagalakshmamma Vadabingi, Venkataswamy Mallepogu, Rani E. Mallapu, Chiranjeevi Pasala, Sumithra Poreddy, Poojitha Bellala, Amineni Umamaheswari, C. Suresh Reddy, Balaji Meriga   +8 more
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Low-concentration contrast abdominopelvic CT: A comparison with high-concentration contrast CT image quality. [PDF]

PLoS One
Yoon S, Park JH, Sym SJ, Yang DH, Lee JS, Park SH.   +5 more
europepmc   +1 more source

Achievability problem for desired formations of linear multi-agent systems [PDF]

Xianfan Wang, J. Zhu, Dianwei Chi, Tiantian HUANG, JunE FENG   +4 more
openalex   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Tropos: An Agent-Oriented Software Development Methodology

Autonomous Agents and Multi-Agent Systems, 2004
P. Bresciani, A. Perini, P. Giorgini, Fausto Giunchiglia, J. Mylopoulos   +4 more
semanticscholar   +1 more source

Biomimetic Synthetic Somatic Markers in the Pixelverse: A Bio-Inspired Framework for Intuitive Artificial Intelligence. [PDF]

Biomimetics (Basel)
Lima V, Martinho D.
europepmc   +1 more source

Cyber Defense through Agentic AI Enabled Automation: An Approach to Reduce Cyber Risk [PDF]

Prashant Vajpayee, Gahangir Hossain
openalex   +1 more source