Results 221 to 230 of about 9,278,000 (361)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

A plant-derived compound activating agent enhances cadmium phytoextraction by Lantana Camara L. [PDF]

BMC Plant Biol
Jia Y, Xie Y, Luo X, Luo Y, He X, Pu Y, Li T, Xu X, Wang G, Zhang S.   +9 more
europepmc   +1 more source

It’s Not All Black and White: Degree of Truthfulness for Risk-Avoiding Agents [PDF]

Eden Hartman, Erel Segal-Halevi, Biaoshuai Tao   +2 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Detection and diagnosis of diabetic retinopathy in retinal fundus images using agentic AI approaches. [PDF]

Sci Rep
Sathya R, Valaramathi A.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Effects of knowledge and importance on responsibility in human-AI decision making. [PDF]

Sci Rep
Tsumura T, Yamada S.
europepmc   +1 more source

Introduction of the crown weevil (<i>Trichosirocalus horridus</i>) as an additional biocontrol agent against nodding thistle

, 1989
C. T. Jessep
openalex   +2 more sources

Molecular and Crystal Structure of Iodixanol, a New X-Ray Contrast Agent. [PDF]

, 1995
Lisbeth Ehnebom Tønnesen, Berit F. Pedersen, Jo Klaveness, Per Halfdan Nielsen, David J. Timmerman-Vaughan, B. Pniewska, Danuta Rasała, Ryszard Gawinecki   +7 more
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source