Results 81 to 90 of about 5,325,715 (296)
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
OPACA: Toward an Open, Language- and Platform-Independent API for Containerized Agents
IEEE AccessWhile multi-agent frameworks can provide many advanced features, they often suffer from not being able to seamlessly interact with the outside world, e.g., with web-services or other multi-agent frameworks.
Benjamin Acar +6 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tissue Microenvironment Modulates CXCR4 Expression and Tumor Metastasis in Neuroblastoma
Neoplasia: An International Journal for Oncology Research, 2007 Neuroblastoma (NB) is derived from intrinsic migratory neural crest cells and has a high potential for distant metastasis. Growing evidence has implicated chemokine receptors, especially CXCR4, which normally control immune and inflammatory cell ...
Libo Zhang +4 more
doaj +1 more source
The agent programming language meta-APL [PDF]
, 2011 . We describe a novel agent programming language, Meta-APL, and give its operational semantics. Meta-APL allows both agent programs and their associated deliberation strategy to be encoded in the same programming language.
Alechina, Natasha +2 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Immunoprevention of non-viral cancers: challenges and strategies for early intervention
Cancer Cell InternationalWhile the effects of cancer vaccines have been extensively studied in the therapeutic setting, research has been more limited in the areas of cancer prevention and interception.
Kajal Biswas +3 more
doaj +1 more source
MACS: Multi-agent COTR system for Defense Contracting [PDF]
, 2000 The field of intelligent multi-agent systems has expanded rapidly in the recent past. Multi-agent architectures and systems are being investigated and continue to develop.
Adya, Monica +7 more
core +1 more source