Results 141 to 150 of about 28,155 (267)

Human fasciolosis diagnosed in the acute phase: A first clinical report in Mexico

Revista de Gastroenterología de México (English Edition), 2016
O.R. Cruz y López, E. Gómez de la Vega, M.E. Cárdenas-Perea, A. Gutiérrez-Dávila, O.J. Tamariz-Cruz   +4 more
doaj   +1 more source

Climate change and health: Surveillance and action duties of the health sector [PDF]

Biomedica
Hernández-Flórez LJ.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Association between Cardiac Metabolic Patterns in Oncological PET/CT and Cardiovascular Risk Factors. Contribution to the Early Investigation of Cardiotoxicity. [PDF]

Arq Bras Cardiol
Smanio PEP.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

[Expanding team-based care for hypertension and cardiovascular risk management with HEARTS in the AmericasAmpliação da atenção baseada em equipe para a gestão do risco de hipertensão arterial e doenças cardiovasculares com a iniciativa HEARTS nas Américas]. [PDF]

Rev Panam Salud Publica
Irazola V, Prado C, Rosende A, Flood D, Tsuyuki R, Ojeda CN, Reyes MV, Otero J, Wellmann IA, Fajardo I, Ridley E, Londoño E, Giraldo G, Bolastig E, Dias BM, Haeberer N, Ordunez P.   +16 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

[Epidemiology of childhood leukemia in Mexico and Latin America: Effects of vulnerability and social justice]. [PDF]

Rev Med Inst Mex Seguro Soc
Núñez-Enríquez JC, Pelayo R, Flores-Lujano J, Allende-López A, Alarcón-Ruiz E, Duarte-Rodríguez DA, Rodríguez-Muñoz AK, Rodríguez-Díaz R, Chávez-Martínez O, Mejía-Aranguré JM.   +9 more
europepmc   +1 more source

Agent/free agent newsreaders

Complexity, 1996
openaire   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source