Results 121 to 130 of about 28,155 (267)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

[Commercially available complementary foods in Argentina and Mexico: An analysis of their nutritional composition, labeling, and promotionAlimentos complementares comercializados na Argentina e no México: análise da composição nutricional, rotulagem e promoção]. [PDF]

Rev Panam Salud Publica
Zapata ME, Veliz P, Rovirosa A, Nessier MC, Risso Patrón V, De Bustos C, Gitz E, Crosbie E.   +7 more
europepmc   +1 more source

Agents, agent architectures and multi-agent systems

, 2010
M.Sc. The use of computer systems has changed over the years. Modern computer systems operate in an environment that is open, distributed and heterogeneous. They have the capability of locating information stored in remote locations and satisfying the interests and objectives of different users.
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

[Regulation of health care financing and delivery: analytic contributions from the perspective of industrial organization and the selection dilemmaRegulação do financiamento e da oferta de serviços de saúde: contribuições analíticas a partir da perspectiva da organização industrial e o dilema da seleção]. [PDF]

Rev Panam Salud Publica
Bascolo E, Houghton N, Debrott Sanchez D, Castillo-Laborde C, Sylvain A.   +4 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Co-developing a community health worker-led hypertension control intervention in Peru through a human-centered design approach. [PDF]

Rev Panam Salud Publica
Williams KN, Campos-Blanco K, Underhill LJ, Tenorio-Much J, de Las Fuentes L, Cordova-Ascona L, Vela-Clavo Z, Cuentas-Canal GM, Mendoza-Velasquez JC, Hurtado R, Geng EH, Checkley W, Gittelsohn J, Davila-Roman VG, Beres LK, Hartinger SM.   +15 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

[Health workers exposed to pesticides: a cross-sectional study involving agents for the control of endemic diseases in the State of Rio de Janeiro, Brazil]. [PDF]

Cad Saude Publica
Vidal PJDSR, Teixeira LR, Gomes L, Silva APDN, Santos MVCD, Carvalho LVB, Rosa ACS, Larentis AL.   +7 more
europepmc   +1 more source