Results 101 to 110 of about 28,155 (267)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Agent-Testing Agent: A Meta-Agent for Automated Testing and Evaluation of Conversational AI Agents

open access: yesProceedings of the 19th Conference of the European Chapter of the Association for Computational Linguistics (Volume 1: Long Papers)
LLM agents are increasingly deployed to plan, retrieve, and write with tools, yet evaluation still leans on static benchmarks and small human studies. We present the Agent-Testing Agent (ATA), a meta-agent that combines static code analysis, designer interrogation, literature mining, and persona-driven adversarial test generation whose difficulty ...
Sameer Komoravolu, Khalil Mrini
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Uso de la metodología GAIA para modelar el comportamiento de personajes en un juego de estrategia en tiempo real

open access: yesRevista Facultad de Ingeniería Universidad de Antioquia, 2010
Los juegos modernos en su permanente búsqueda por capturar más la atención de sus jugadores, requieren de técnicas de Inteligencia Artificial que les permita a los personajes asumir comportamientos más cercanos o parecidos a la realidad. Para lograr esto,
Norman Muñoz   +4 more
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Interfaces dinámicas en dispositivos móviles

open access: yesPublicaciones en Ciencias y Tecnología, 2008
En los últimos años se ha incrementado el uso de dispositivos móviles, los teléfonos celulares por ejemplo, han dejado de ser sólo instrumentos de transmisión de voz para convertirse en aparatos capaces de procesar y transmitir información. El desarrollo
Rodolfo Canelón   +2 more
doaj  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Modelo y desarrollo de W-planner: sistema multiagente on-line aplicado al turismo electrónico

open access: yesIngeniería y Ciencia, 2005
Este trabajo introduce el llamado ¿problema del turista¿ y presenta una solución basada en un sistema multiagente. Un grupo de agentes que usan un sistema para identificar acciones y planes es capaz de encontrar el itinerario más adecuado para un turista
Luis F. Castillo   +2 more
doaj  

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