Results 181 to 190 of about 5,277,218 (357)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Association of Corneal Biomechanical Properties with Fingertip-Measured Advanced Glycation End Products and Carotenoids in Glaucoma Patients. [PDF]

J Clin Med
Takagi K, Ohtani H, Ida C, Koike M, Murakami K, Tanito M.   +5 more
europepmc   +1 more source

Zircon U–Pb age and its geological significance of late Carboniferous and Early Cretaceous adakitic granites from eastern margin of the Abukuma Mountains, Japan

, 2014
Nobutaka Tsuchiya, Tomoyo Takeda, Kenichiro Tani, Tatsuro Adachi, Nobuhiko Nakano, Yasuhito Osanai, Jun‐Ichi Kimura   +6 more
openalex   +2 more sources

Hispanic ethnicity is associated with younger age at presentation but worse survival in acute myeloid leukemia [PDF]

, 2017
Karine Darbinyan, Aditi Shastri, Anjali Budhathoki, Daniel Helbig, Rose Snyder, Kith Pradhan, Junaid Saleh-Esa, Noah Kornblum, Adam Binder, Swati Goel, Murali Janakiram, Olga Derman, Kira Gritsman, Ulrich Steidl, Ira Braunschweig, Amit Verma, Ioannis Mantzaris   +16 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Minimally Destructive Radiocarbon Dating of Bone. [PDF]

Rapid Commun Mass Spectrom
Higham T, Luftensteiner K, van der Sluis L, Giannì M, Wiegele M, Papadogianni A, Steier P, Gruber D, Schmidt B, Schmidt K, Belinski A, Mensan R, Kozlikin M, Shunkov M, Neruda P, Nerudová Z, Horejs B, Schulze J, Douka K, Stafford TW.   +19 more
europepmc   +1 more source

Cyber Security Threats and Countermeasures in Digital Age

Manikant Thakur
openalex   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Updated chronologies for North American small mammal fossil localities in the Neotoma Paleoecology Database. [PDF]

Sci Data
Syverson VJP, Goring SJ, Cullen N, Jarzyna MA, Bellvé AM, Martindale A, Blois JL.   +6 more
europepmc   +1 more source

Redefinition of the Cretaceous terrigenous strata in the northeastern Toyama Prefecture based on U-Pb ages of zircon

, 2015
Makoto Takeuchi, Masahiro Ohkawa, Kentaro Kawahara, Satoru Tomita, Hideharu Yokota, Tetsuya Tokiwa, Ryuta Furukawa   +6 more
openalex   +2 more sources