Results 131 to 140 of about 86,089 (326)

European Society for the Study of Coeliac Disease 2025 Updated Guidelines on the Diagnosis and Management of Coeliac Disease in Adults. Part 1: Diagnostic Approach

open access: yesUnited European Gastroenterology Journal, EarlyView.
Infographic. This infographic summarizes the diagnostic approach to CeD in adults, including initial serological testing, histological confirmation, criteria for a no‐biopsy diagnosis, seronegative CeD, potential CeD, and the role of gluten challenge. Source: Authors' own creation (based on current clinical guidelines).
Abdulbaqi Al‐Toma   +20 more
wiley   +1 more source

Aging Reduces Intestinal Stem Cell Activity in Killifish and Intermittent Fasting Reverses Intestinal Gene Expression Patterns

open access: yesAging Cell, EarlyView.
Intestinal stem cells occur in clusters, and the cycle time of stem cells increases with age. The age‐dependent decline in structural intestinal tissue homeostasis is associated with a decline in stem cell activity. Aging causes significant changes in intestinal gene expression; intermittent fasting from adulthood onwards results in a gene expression ...
Michael Kothmayer   +12 more
wiley   +1 more source

A unique case of red blood cell agglutination reaction on glass surface in otherwise normal sample

open access: yesAsian Journal of Transfusion Science
Autoimmune hemolytic anemias (AIHAs) are not very common, and autoimmunity is an important cause of hemolytic anemia, especially in female population. Some primary AIHAs are cold or warm agglutinin mediated anemia. Autoimmune reaction leads to macrophage
Neema Tiwari   +3 more
doaj   +1 more source

Lactate inhibits glucose‐induced zigzag motility and enhances linear motility in bull spermatozoa by suppressing glycolysis

open access: yesAndrology, EarlyView.
Abstract Background Energy metabolism and substrate balance are critical determinants of sperm motility and fertility. Linear motility is necessary for sperm forward movement, whereas hyperactivated motility is a prerequisite for fertilization. The preference of metabolic pathways depends on substrate availability which controls sperm motility. However,
Md Faizul Hossain Miraz   +4 more
wiley   +1 more source

Astragaloside IV alleviates hypoxic pulmonary hypertension by inhibiting RELM‐β to reduce PINK1/Parkin‐mediated mitophagy in pulmonary artery smooth muscle cells (PASMCs)

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Hypoxic pulmonary hypertension (HPH) is a chronic disorder marked by irreversible pulmonary vascular remodelling (PVR) and pulmonary artery smooth muscle cell (PASMC) dysfunction. Astragaloside IV (AS‐IV), a natural saponin from Astragalus, shows potential in HPH management. This study explores AS‐IV's protective effect on PVR in
Rongzhen Ding   +12 more
wiley   +1 more source

Transcription Factor TCF12‐Mediated Maternal Gene Expressions in Mouse Oocyte Are Prerequisites of Successful Fertilisation and Zygotic Genome Activation

open access: yesCell Proliferation, EarlyView.
Maternal TCF12 ensures the competence of fertilisation by controlling the expression of Astl and the proper location of cortical granules. Furthermore, maternal TCF12 maintains the phosphatase activity of PP2A by regulating the expression of Arpp19. Oocyte‐specific deletion of Tcf12 leads to fertilisation defects as well as ZGA failure at the 2‐cell ...
Lan‐Rui Cao   +7 more
wiley   +1 more source

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