Results 161 to 170 of about 109,705 (362)

Targeting CA2 Perineuronal Nets Restores Recognition Memory and Theta Oscillations in Aged Mice

open access: yesAging Cell, EarlyView.
Targeting CA2 perineuronal nets restores social/non‐social recognition memory and theta oscillations in aged mice: Aged mice displayed deficits in both social and object recognition memory, which were accompanied by enhanced perineuronal nets (PNNs) density and reduced theta power in the dCA2 region.
Sonam Fathima Mehak   +5 more
wiley   +1 more source

BubR1 Insufficiency Drives Transcriptomic Alterations and Pathology Associated With Cardiac Aging and Heart Failure

open access: yesAging Cell, EarlyView.
Transcriptomic and cellular analyses of BubR1 hypomorphic hearts reveal disruptions in key pathways and upregulation of markers linked to impaired cardiac structure and function. Comparative transcriptomic analysis shows that BubR1 insufficiency mirrors changes seen in aged and failing hearts. A key finding of this study is that BubR1 levels decline in
Renju Pun   +13 more
wiley   +1 more source

Lectin Activity in Gut Extract of Culex pipiens.

open access: yesJournal of Arthropod-Borne Diseases, 2013
Background: The role of lectins is important in interaction between pathogens and mosquito vectors. This study was performed to identify agglutinin activities of protein molecules on the midgut of Culex pipiens.
Mona Koosha   +4 more
doaj  

Comparative analysis of formyl peptide receptor 1 and formyl peptide receptor 2 reveals shared and preserved signalling profiles

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose The pattern recognition receptors, formyl peptide receptors, FPR1 and FPR2, are G protein‐coupled receptors that recognize many different pathogen‐ and host‐derived ligands. While FPR1 conveys pro‐inflammatory signals, FPR2 is linked with pro‐resolving outcomes.
Denise Pajonczyk   +5 more
wiley   +1 more source

The Application of Polymeric Nanoparticles as Drug Delivery Carriers to Cells in Neurodegenerative Diseases

open access: yesCell Proliferation, EarlyView.
Polymeric nanoparticles represent promising drug (gene) delivery carriers to the brain due to their unique advantages to facilitate the penetration of blood–brain barrier and endocytosis of neuronal cells in neurodegenerative diseases. ABSTRACT In spite of great advances in modern medicine, there are a few effective strategies for the treatment of ...
Lian Jin   +4 more
wiley   +1 more source

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