Results 221 to 230 of about 109,705 (362)

SARM1 Exacerbates Pressure Overload‐Induced Cardiac Hypertrophy and Heart Failure by Enhancing NAD+ Metabolism

open access: yesThe FASEB Journal, Volume 39, Issue 14, 31 July 2025.
Under pathological conditions, elevated hydrolytic activity of SARM1 significantly depletes NAD+ levels and compromises electron transport chain (ETC) function. This disruption induces mitochondrial dysfunction, elevates ROS production, reduces ATP synthesis, and increases inflammation, which collectively accelerate cardiac hypertrophy (CH) and ...
Hui‐Ting Shi   +11 more
wiley   +1 more source

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

open access: yesFEBS Open Bio, Volume 15, Issue 7, Page 1068-1078, July 2025.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu   +6 more
wiley   +1 more source

Agglutinins and Incomplete Antibodies after a Single Antigenic Inoculation in Normal and Rheumatic Individuals

open access: green, 1955
Verena Wagner   +5 more
openalex   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 17, July 4, 2025.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray   +2 more
wiley   +1 more source

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