Results 41 to 50 of about 86,089 (326)

Clinical characteristics and outcome of patients with autoimmune hemolytic anemia (AIHA) uniformly defined as primary by a diagnostic work-up [PDF]

, 2016
Primary autoimmune hemolytic anemia (P-AIHA) is a relatively uncommon and hetereogeneous disease characterized by the destruction of red blood cells due to anti-erythrocyte autoantibodies (AeAbs) in the absence of an associated disease [1–3].
ARMIENTO, DANIELE, CARONNA, Roberto, COLAFIGLI, GIOIA, Coluzzi, S, De Propris, Ms, FERRETTI, ANTONIETTA, FOA, Roberto, GIOVANNETTI, GIANLUCA, GIRELLI, Gabriella, GUARINI, Anna, LA ROCCA, URSULA, MAURO, Francesca Romana, MOLICA, MATTEO, Morano, G, Paoloni, F, Trastulli, F   +15 more
core   +1 more source

Perfusable Brain Microvascular Network‐On‐Chip Model to Study Flavivirus NS1‐Induced Endothelial Dysfunction

Advanced Functional Materials, EarlyView.
This study presents a microfluidic brain microvascular network‐on‐chip (BMVasChip) to investigate endothelial barrier dysfunction caused by flavivirus non‐structural protein 1 (NS1), including virus‐ and time‐dependent vascular damage, leakiness, and dysfunction.
Monika Rajput, Yen‐Ting Tung, Yu‐Chi Chen, Min Jae Song, Marc Ferrer, Emily M. Lee   +5 more
wiley   +1 more source

Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix

Advanced Functional Materials, EarlyView.
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt, Jens Timmer, Elisabetta Ada Cavalcanti‐Adam   +2 more
wiley   +1 more source

A novel method for demonstrating cold agglutinin disease: a case report

Journal of Medical Case Reports, 2018
Background Cold agglutinin disease is a rare disorder characterized by an autoimmune hemolytic anemia occurring at low temperatures. Physical examination findings, often limited to acrocyanosis, are combined with a thermal amplitude test to help ...
Thomas A. Vo, Zack Oakey, Yasir A. Khan, Donald S. Minckler   +3 more
doaj   +1 more source

FGB1 and WSC3 are in planta-induced beta-glucan-binding fungal lectins with different functions [PDF]

, 2019
In the root endophyte Serendipita indica, several lectin-like members of the expanded multigene family of WSC proteins are transcriptionally induced in planta and are potentially involved in beta-glucan remodeling at the fungal cell wall.
Becker, S., Fesel, P., Hehemann, J., Lahrmann, U., Langen, G., Neumann, U., Wawra, S., Widmer, H., Zuccaro, A.   +8 more
core   +2 more sources

Protein glycosylation as a diagnostic and prognostic marker of chronic inflammatory gastrointestinal and liver diseases [PDF]

, 2020
Glycans are sequences of carbohydrates that are added to proteins or lipids to modulate their structure and function. Glycans modify proteins required for regulation of immune cells, and alterations have been associated with inflammatory conditions.
Callewaert, Nico, Colombel, Jean-Frederic, Dias, Ana M, Pinho, Salome S, Van Vlierberghe, Hans, Verhelst, Xavier, Vermeire, Severine   +6 more
core   +1 more source

Smart Nanogels as Enzyme‐Driven Nanomotors for Navigating Viscous Physiological Barriers

Advanced Functional Materials, EarlyView.
Two families of urease‐powered nanomotors (NMs), with and without a p‐(2‐hydroxyethyl methacrylate) (p‐HEMA) shell, have been successfully prepared. Both types exhibit effective motion in highly viscous synovial fluid media at low urea concentrations (25 mM).
David Esporrín‐Ubieto, Noelia Ruiz‐González, Valerio Di Carlo, Daniel Sánchez‐deAlcázar, Florencia Lezcano, Anna Pushkareva Fazullina, Samuel Sánchez   +6 more
wiley   +1 more source

Bi‐Functional Topospecific Nanoparticles to Promote Immune‐Tumor Cell Engagement as A New Immunotherapeutic Strategy

Advanced Materials, EarlyView.
A Janus‐engineered nanoplatform (J‐pHLIP‐PD1), featuring separate tumor‐ and immune‐targeting faces, bridges melanoma cells and cytotoxic T lymphocytes using toposelective pHLIP and anti‐PD‐1 presentation. This strategy elicits robust antitumor responses, promotes immunogenic tumor cell death, suppresses lung metastasis in vivo, and provides a modular,
Alba Ortuño‐Bernal, Sandra Clara‐Trujillo, Elena Lucena‐Sánchez, Francisco J. Hicke, Andrea Escudero, Sandra Pradana‐López, Nelia Jiménez‐Alduan, Paula Díez, Alba García‐Fernández, Ramón Martínez‐Máñez   +9 more
wiley   +1 more source

Fractionation of human immune γ-globulin [PDF]

, 1950
Equine and bovine serum proteins have recently been fractionated by means of a physical method utilizing an electrophoretic adaptation of the principles of the Clusius column (l-4), first described and tested by Kirkwood (5) and Nielsen (6).
Brown, Raymond A., Cann, John R., Hink, John H., Jr., Kirkwood, John G.   +3 more
core  

Giardia Cyst Wall Protein 1 Is a Lectin That Binds to Curled Fibrils of the GalNAc Homopolymer [PDF]

, 2010
The infectious and diagnostic stage of Giardia lamblia (also known as G. intestinalis or G. duodenalis) is the cyst. The Giardia cyst wall contains fibrils of a unique β-1,3-linked N-acetylgalactosamine (GalNAc) homopolymer and at least three cyst wall ...
Bullitt, Esther, Carpentieri, Andrea, Chatterjee, Aparajita, Costello, Catherine E., Ratner, Daniel M., Robbins, Phillips W., Samuelson, John   +6 more
core   +5 more sources