Results 51 to 60 of about 86,089 (326)

PRDM16 Reduces Cellular Senescence by Upregulating GSTM1

Advanced Science, EarlyView.
Cellular senescence drives aging and aging‐related organ disorders, yet PRDM16's role remains unexplored. This work uncovers that PRDM16 decreases significantly in aged organs, while its loss accelerates cellular senescence and aging‐related organ injury.
Qian Yuan, Yuting Zhu, Ben Tang, Yaru Xie, Mingcun Hu, Hua Su, Youhua Liu, Chun Zhang   +7 more
wiley   +1 more source

A biophysical elucidation for less toxicity of Agglutinin than Abrin-a from the Seeds of Abrus Precatorius in consequence of crystal structure

Journal of Biomedical Science, 2010
X-ray crystal structure determination of agglutinin from abrus precatorius in Taiwan is presented. The crystal structure of agglutinin, a type II ribosome-inactivating protein (RIP) from the seeds of Abrus precatorius in Taiwan, has been determined from ...
Liu Chao-Lin, Lu Tian-Huey, Cheng Jack, Lin Jung-Yaw   +3 more
doaj   +1 more source

Differentiation, Quantification and Identification of Abrin and Abrus precatorius Agglutinin

Toxins, 2021
Abrin, the toxic lectin from the rosary pea plant Abrus precatorius, has gained considerable interest in the recent past due to its potential malevolent use.
Sylvia Worbs, Bettina Kampa, Martin Skiba, Eva-Maria Hansbauer, Daniel Stern, Hervé Volland, François Becher, Stéphanie Simon, Martin B. Dorner, Brigitte G. Dorner   +9 more
doaj   +1 more source

Controlling sap-sucking insect pests with recombinant endophytes expressing plant lectin [PDF]

, 2010
We developed a novel pest management strategy, which uses endophytes to express anti-pest plant lectins. Fungal endophyte of Chaetomium globosum YY-11 with anti-fungi activities was isolated from rape seedlings, and bacterial endophytes of SJ-10 ...
Gaofu Qi, Nan Lan, Xianfang Zhang, Xinrong Ma, Xiuyun Zhao   +4 more
core   +1 more source

Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy [PDF]

, 2014
Chronic neurohormonal and mechanical stresses are central fea-tures of heart disease. Increasing evidence supports a role forthe transient receptor potential canonical channels TRPC3 andTRPC6 in this pathophysiology.
Andersen, Asger, Birnbaumer, Lutz, Jo, Su-Hyun, Kass, David A., Lee, Dong-ik, Lepore, John J., Liu, Ting, Marino, Joseph P., Rainer, Peter P., Schnackenberg, Christine G., Seo, Kinya, Shalkey Hahn, Virginia, Willette, Robert N., Xu, Xiaoping   +13 more
core   +1 more source

Structural and Functional Versatility of the Amyloidogenic Non‐Amidated Variant of the Antimicrobial Peptide Citropin 1.3

Advanced Science, EarlyView.
Citropin 1.3 is an antimicrobial peptide derived from amphibians that forms amyloid structures. Here, the structural and functional properties of citropin 1.3 are characterized. Using high‐resolution imaging approaches, a variety of canonical and undescribed fibril morphologies are identified.
Fabio Strati, Mariana Pigozzi Cali, Yehudi Bloch, Siavash Mostafavi, Jim Monistrol, Aleksandr Golubev, Bader Rayan, Emil Gustavsson, Meytal Landau   +8 more
wiley   +1 more source

Analysis of castor bean ribosome-inactivating proteins and their gene expression during seed development

Genetics and Molecular Biology, 2013
Ribosome-inactivating proteins (RIPs) are enzymes that inhibit protein synthesis after depurination of a specific adenine in rRNA. The RIP family members are classified as type I RIPs that contain an RNA-N-glycosidase domain and type II RIPs that contain
Guilherme Loss-Morais, Andreia Carina Turchetto-Zolet, Matheus Etges, Alexandro Cagliari, Ana Paula Körbes, Felipe dos Santos Maraschin, Márcia Margis-Pinheiro, Rogério Margis   +7 more
doaj  

Characterization of anti-soybean agglutinin (SBA) IgY antibodies: a new strategy for neutralization of the detrimental biological activity of SBA

Frontiers in Veterinary Science
Anti-soybean agglutinin (SBA) IgY was produced, and its potential to neutralize the haemagglutinating activity of SBA in vitro was tested. Thirty-five-week-old hens [treatment (n = 5) and control (n = 5)] were immunized with SBA or injected with saline 4
Nancy Ruiz Díaz, Nancy Ruiz Díaz, Carlos Cisternas, Mauricio Silva, Mauricio Silva, Adrián Hernández, Adrián Hernández, Pablo Chacana   +7 more
doaj   +1 more source

N-glycosylation pattern of human placental insulin-like growth factor and insulin receptors in well-controlled pregestational diabetes mellitus [PDF]

Journal of Medical Biochemistry, 2012
Diabetes mellitus is a complex disease that leads to alterations in the glycosylation of proteins. Insulin-like growth factor and insulin receptors are involved in the regulation of fetal and placental growth and development.
Robajac Dragana, Masnikosa Romana, Filimonović Dejan, Miković Željko, Nedić Olgica   +4 more
doaj  

Rim Pathway-Mediated Alterations in the Fungal Cell Wall Influence Immune Recognition and Inflammation [PDF]

, 2017
ACKNOWLEDGMENTS We acknowledge Jennifer Lodge, Woei Lam, and Rajendra Upadhya for developing and sharing the chitin and chitosan MTBH assay. We thank Todd Brennan of Duke University for providing MyD88-deficient mice.
Carol Munro, Chrissy M. Leopold Wager, Floyd L. Wormley, J. Andrew Alspaugh, Jeanette Wagener, Kyla S. Ost, Louise Walker, Michael Lorenz, Shannon K. Esher   +8 more
core   +3 more sources