Results 61 to 70 of about 86,089 (326)
Sutimlimab in Cold Agglutinin Disease
New England Journal of Medicine, 2021 Cold agglutinin disease is a rare autoimmune hemolytic anemia characterized by hemolysis that is caused by activation of the classic complement pathway. Sutimlimab, a humanized monoclonal antibody, selectively targets the C1s protein, a C1 complex serine protease responsible for activating this pathway.We conducted a 26-week multicenter, open-label ...
Röth, Alexander +15 more
openaire +3 more sources
Adamts1 Exacerbates Post‐Myocardial Infarction Scar Formation via Mechanosensing of Integrin α8
Advanced Science, EarlyView.Proposed mechanistic model of ADAMTS1‐ITGα8 mechanotransduction in post‐MI scar formation. Schematic illustration showing the mechanistic pathway by which endothelial cell (EC) derived Adamts1 regulates cardiac fibroblast activation through ITGα8‐mediated mechanotransduction following myocardial infarction (MI).
Chun‐Yan Kong +11 more
wiley +1 more source
Localization of axonally transported 125I-wheat germ agglutinin beneath the plasma membrane of chick retinal ganglion cells. [PDF]
, 1983 The distribution of 125I-wheat germ agglutinin (WGA) transported by axons of chick retinal ganglion cells to layer d of the optic tectum was studied by electron microscopic autoradiography.
LaVail, JH, McDonald, DM, Sugino, IK
core
Immune myopathies with perimysial pathology: Clinical and laboratory features [PDF]
, 2018 ObjectiveImmune myopathies with perimysial pathology (IMPP) have a combination of damage to perimysial connective tissue and muscle fiber necrosis, more prominent near the perimysium.
Bucelli, Robert C, Pestronk, Alan
core +2 more sources
Advanced Science, EarlyView.This study identifies the mitochondrial protein RTA9, a member of the Domain of Unknown Function 641 family, together with its partner S40, as key regulators of aphid resistance in maize. RTA9 promotes S40 degradation and modulates reactive oxygen species accumulation.
Chuanhong Wang +12 more
wiley +1 more source
Glucocorticoid-Responsive Cold Agglutinin Disease in a Patient with Rheumatoid Arthritis
Case Reports in Rheumatology, 2015 A 57-year-old man with rheumatoid arthritis developed severe anemia during treatment with adalimumab plus methotrexate. Cold agglutinin disease was diagnosed because haptoglobin was undetectable, cold agglutinin was positive (1 : 2048), and the direct ...
Kyoko Honne +4 more
doaj +1 more source
Jurnal Kedokteran Hewan, 2015 Penelitian ini bertujuan mengkaji efisiensi pencernaan kerbau rawa dengan mengidentifikasi jenis dan distribusi glikokonjugat pada daerah abomasum kerbau rawa. Enam ekor kerbau rawa jantan 2,5 tahun dan berat badan 300-400 kg digunakan dalam penelitian
Anni Nurliani +2 more
doaj +1 more source
Per os infectivity of white spot syndrome virus (WSSV) in white-legged shrimp (Litopenaeus vannamei) and role of peritrophic membrane [PDF]
, 2016 As earlier observations on peroral infectivity of WSSV in white-legged shrimp are conflicting, here, a standardized peroral intubation technique was used to examine (i) the role of the physical composition of the viral inoculum and (ii) the barrier ...
Bossier, Peter +5 more
core +1 more source
Advanced Science, EarlyView.Binding of Doxorubicin to ALYREF disrupts its phase‐separated condensate and induces DNA damage and apoptosis in cardiomyocytes Abstract The clinical utility of the anticancer agent doxorubicin (DOX) is limited by its dose‐dependent cardiotoxicity.
Xinlu Gao +20 more
wiley +1 more source
Development of Lectin-Linked Immunomagnetic Separation for the Detection of Hepatitis A Virus
Viruses, 2014 The accuracy and sensitivity of PCR-based methods for detection of hepatitis A virus (HAV) are dependent on the methods used to separate and concentrate the HAV from the infected cells.
Sang-Mu Ko +9 more
doaj +1 more source