Results 181 to 190 of about 18,578 (279)

Cardiac Slc25a49‐Mediated Energy Reprogramming Governs Doxorubicin‐Induced Cardiomyopathy through the G6P–AP‐1–Sln Axis

open access: yesAdvanced Science, Volume 12, Issue 26, July 10, 2025.
Doxorubicin‐induced cardiomyopathy involves mitochondrial energy metabolism dysfunction, exacerbated by cardiomyocyte‐specific Slc25a49 deficiency via oxidative phosphorylation (OXPHOS) suppression and glycolysis activation. The Slc25a49–glucose‐6‐phosphate (G6P)–activator protein‐1 (AP‐1) axis drives myocardial injury by upregulating Sln, disrupting ...
Sitong Wan   +16 more
wiley   +1 more source

Human Cervix Chip: A Preclinical Model for Studying the Role of the Cervical Mucosa and Microbiome in Female Reproductive Health

open access: yesBioEssays, Volume 47, Issue 7, July 2025.
The microfluidic Cervix Chip is an in vitro model of the human cervix lined by cervical epithelium interfaced with stromal cells cultured under dynamic flow that represents a new preclinical platform for studying mucosal immunity, host‐microbiome interactions, infections, fertility, and pregnancy health.
Zohreh Izadifar   +4 more
wiley   +1 more source

THERMAL DIFFERENTIATION BETWEEN H AND O AGGLUTININS I [PDF]

open access: bronze, 1955
Nicholas J. Menolasino   +2 more
openalex   +1 more source

Small Intestine on a Chip Demonstrates Physiologic Mucus Secretion in the Presence of Lacticaseibacillus rhamnosus Biofilm

open access: yesBiotechnology and Bioengineering, Volume 122, Issue 7, Page 1816-1827, July 2025.
Dash and coworkers have fabricated a small intestine on a chip, which encapsulates the physiology and biofilm of the small intestinal epithelium. The dynamic system showed villus differentiation within 5 days of flow, and the mucus layer and biofilm showed small intestinal characteristics.
Sanat Kumar Dash   +2 more
wiley   +1 more source

Indirect hemagglutination assay for diagnosing brucellosis: Past, present, and future. [PDF]

open access: yesVet World
Mikailov MM   +4 more
europepmc   +1 more source

Neonatal NLRP3 Inflammasome Activation Leads to Perineuronal Net Deficits in Early Adulthood

open access: yesDevelopmental Neurobiology, Volume 85, Issue 3, July 2025.
ABSTRACT Perineuronal nets (PNNs) are specialized extracellular matrix structures that surround certain neurons and play a critical role in protecting neurons from oxidative stress and maintaining synaptic stability in the central nervous system. They have roles in memory formation, and their loss has been linked to various mental alterations, such as ...
Emre Tarakcioglu   +3 more
wiley   +1 more source

Alfalfa Flavonoids Mitigate Salmonella‐Induced Colitis via the Keap1‐Nrf2 and TLR4/NF‐κB/COX‐2 Pathways

open access: yesFood Frontiers, Volume 6, Issue 4, Page 1867-1886, July 2025.
Alfalfa flavonoids (AF) protected against Salmonella‐induced colitis by reducing inflammation and oxidative stress. AF inhibited the TLR4/IκB/NF‐κB/COX‐2 pathway and NLRP3 inflammasome, lowering pro‐inflammatory cytokines, while activating Keap1‐Nrf2 to boost antioxidants (e.g., HO‐1, NQO1, SOD, GPx), decreasing ROS‐driven oxidative stress.
Xiaoli Qin   +11 more
wiley   +1 more source

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