Results 201 to 210 of about 18,578 (279)

A metastasis‐associated pannexin‐1 mutant (Panx11‐89) forms a minimalist ATP release channel

open access: yesThe FEBS Journal, Volume 292, Issue 13, Page 3378-3396, July 2025.
A truncation mutant of Panx1 (Panx11‐89), enriched in metastatic breast cancer cells, is capable of forming a large ATP‐permeable membrane channel despite containing only 20% of the amino‐terminal amino acids of the wild‐type channel protein (wtPanx1). However, cells expressing Panx11‐89 alone die, whereas co‐expression of wtPanx1 is protective.
Junjie Wang   +5 more
wiley   +1 more source

Siglec-targeted liposomes to identify sialoglycans present on fungal pathogens. [PDF]

open access: yesAntimicrob Agents Chemother
Ambati S   +7 more
europepmc   +1 more source

The Association of Systemic Inflammation, Wound Bioburden and Total Bacterial Counts With Healing Outcomes in Older Adults With Chronic Venous Leg Ulcers

open access: yesInternational Wound Journal, Volume 22, Issue 7, July 2025.
ABSTRACT This substudy utilised data from a prospective, longitudinal study aimed to investigate associations between systemic inflammation, wound bioburden, total bacterial counts and wound healing outcomes over 8 weeks in older adults with chronic venous leg ulcers (CVLUs). Participants were receiving standardised weekly wound debridement.
Junglyun Kim   +8 more
wiley   +1 more source

Astaxanthin Prevented Acute Alcoholic Cardiomyopathy by Maintenance of Mitophagy‐Mediated Mitochondrial Homeostasis

open access: yesJournal of Cellular and Molecular Medicine, Volume 29, Issue 13, July 2025.
ABSTRACT Acute alcoholism commonly targets the myocardium, triggering acute alcoholic cardiomyopathy (ACM). Strong evidence suggested that mitochondrial dysfunction‐induced myocardial oxidative stress is involved in the subcellular pathogenesis of acute ACM. We investigated whether astaxanthin (AST), an antioxidant lutein carotenoid, prevents acute ACM
Guoyong Fan   +11 more
wiley   +1 more source

Myeloid MyD88 Mediates Macrophage Infiltration and Activation in Ang II‐Induced Cardiac Hypertrophy

open access: yesJournal of Cellular and Molecular Medicine, Volume 29, Issue 14, July 2025.
ABSTRACT Hypertension is the leading cause of cardiac remodelling and heart failure. Recent evidence has highlighted the role of the non‐hemodynamic function of angiotensin II in hypertension. MyD88 is the canonical adaptor of TLRs and IL‐1Rs, which serves as the central node in regulating inflammatory responses.
Ke Lin   +6 more
wiley   +1 more source

Sex Specific Effects of Environmental Toxin‐Derived Alpha Synuclein on Enteric Neuronal‐Epithelial Interactions

open access: yesNeurogastroenterology &Motility, Volume 37, Issue 7, July 2025.
Sex‐specific alterations in intestinal neuronal‐epithelial interactions between calcitonin gene related peptide (CGRP) and goblet cells secondary to elevated enteric alpha synuclein (aSyn) potentially contribute to gastrointestinal dysfunction in Parkinson's Disease (PD). ABSTRACT Background Parkinson's Disease (PD) is a neurodegenerative disorder with
Hayley N. Templeton   +5 more
wiley   +1 more source

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