Results 71 to 80 of about 53,073 (361)

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Cold Agglutinin Disease Unfurled in Laboratory and Blood Bank: A Little Poignant Observation Can Speak a Lot!

Archives of Medicine and Health Sciences
Autoimmune hemolytic anemias (AIHAs) are hemolytic anemias characterized by the production of autoantibodies against surface antigens on red blood cells.
Archana Shetty, Gurudatta Murthy, Bharadwaj Golithadka   +2 more
doaj   +1 more source

Methodological framework for a participatory study to evaluate the socio-economic factors impairing the efficacy of animal health surveillance systems [PDF]

, 2012
The need to set up efficient, sustainable surveillance networks of animal diseases is a major issue for worldwide animal and public health management. In developing countries the need to assess the efficiency and sustainability of surveillance systems is
Antoine-Moussiaux, Nicolas, Binot, Aurélie, Delabouglise, Alexis, Duboz, Raphaël, Nguyen, V.K., Peyre, Marie-Isabelle, Vu Dinh, T.   +6 more
core  

Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding [PDF]

, 2015
The role of the primary cilium in key signaling pathways depends on dynamic regulation of ciliary membrane protein composition, yet we know little about the motors or membrane events that regulate ciliary membrane protein trafficking in existing ...
Adair, Bakeberg, Belzile, Bergman, Cao, Chacon-Heszele, Chih, Dentler, Dorn, Engel, Ferris, Firestone, Garcia-Gonzalo, Gerdes, Goetz, Goodenough, Goodenough, Hildebrandt, Hogan, Hu, Hunnicutt, Hunnicutt, Hyman, Kim, Kong, Kubo, Lancaster, Lin, Liu, Liu, Malicki, Meng, Milenkovic, Molla-Herman, Mukhopadhyay, Mukhopadhyay, Nachury, Ning, Ocbina, Pasquale, Pazour, Pazour, Pedersen, Pijst, Pijst, Rohatgi, Rohatgi, Rosenbaum, Sang, Shih, Snell, Snell, Snell, Tai, Wang, Wang, Wang, Weise, Wiese, Williams, Wilson, Wood, Wood, Ye   +63 more
core   +3 more sources

Amphiphilic Low-Molecular-Weight Gelators Bearing β-S-N-Acetylglucosamine Linked to a Tartaric Acid Scaffold: Synthesis, Self-Assembly and Wheat Germ Agglutinin Binding [PDF]

, 2023
Vicente Leafar Peña García, Pablo H. Di Chenna, Marı́a Laura Uhrig   +2 more
openalex   +1 more source

Bacteriophage‐Mimetic DNA Origami Needle for Targeted Membrane Penetration and Cytosolic Cargo Delivery

Advanced Science, EarlyView.
We designed a synthetic DNA origami needle‐like structure inspired by bacteriophages for targeted drug delivery. Functionalized with trastuzumab antibodies, cholesterol, and dyes, it selectively targets SKBR3 cancer cells. A glutathione‐triggered dye payload enables controlled release, and delivery is verified using confocal microscopy and live cell ...
Anirban Samanta, Mette Galsgaard Malle, Emily Tsang, Marjan Omer, Mads K. Skaanning, Sarah Youssef, Jørgen Kjems, Kurt V. Gothelf   +7 more
wiley   +1 more source

Glucocorticoid-Responsive Cold Agglutinin Disease in a Patient with Rheumatoid Arthritis

Case Reports in Rheumatology, 2015
A 57-year-old man with rheumatoid arthritis developed severe anemia during treatment with adalimumab plus methotrexate. Cold agglutinin disease was diagnosed because haptoglobin was undetectable, cold agglutinin was positive (1 : 2048), and the direct ...
Kyoko Honne, Takao Nagashima, Masahiro Iwamoto, Toyomi Kamesaki, Seiji Minota   +4 more
doaj   +1 more source

Anaesthetic management for cardiac surgery in patients with cold haemagglutinin disease

Indian Journal of Anaesthesia, 2018
Cold haemagglutination is a primary or acquired autoimmune disease involving antibodies that lead to agglutination of red blood cells at low temperature followed by complement fixation and haemolysis on rewarming.
Jasbir S Khanuja, Neelam Aggarwal, Rajat Kapur, Sushant Srivastava   +3 more
doaj   +1 more source

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source

Níveis de aglutininas anti-tifoídicas em esquistossomóticos hepato-esplênicos Levels of antityphoid agglutinins in hepatosplenic schistosomiasis patients

Revista de Saúde Pública, 1982
Dois grupos, constituídos de 43 esquistossomóticos hepato-esplênicos e 83 indivíduos controle, foram analisados quanto à prevalência de aglutininas anti-tifoídicas.
Maria Aparecida Shikanai Yasuda, Rubens Guimarães Ferri, Paulo Hideki Yasuda, Celeste Fava Netto, Guilherme Rodrigues da Silva, José Maria Ferreira   +5 more
doaj   +1 more source