Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Combining disaggregate forecasts or combining disaggregate information to forecast an aggregate [PDF]
To forecast an aggregate, we propose adding disaggregate variables, instead of combining forecasts of those disaggregates or forecasting by a univariate aggregate model. New analytical results show the effects of changing coefficients, mis-specification,
Hubrich, Kirstin, Hendry, David F.
core
Time varying Markov process with partially observed aggregate data: An application to coronavirus. [PDF]
J Econom, 2023 Gourieroux C, Jasiak J.
europepmc +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
A framework for prospective, adaptive meta-analysis (FAME) of aggregate data from randomised trials. [PDF]
PLoS Med, 2021 Tierney JF +8 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Pharmacometric estimation methods for aggregate data, including data simulated from other pharmacometric models. [PDF]
J Pharmacokinet Pharmacodyn, 2021 Välitalo PAJ.
europepmc +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Forecasting aggregate and disaggregates with common features. [PDF]
The paper is focused on providing joint consistent forecasts for an aggregate and all its components and in showing that this indirect forecast of the aggregate is at least as accurate as the direct one.
Mayo, Iván, Espasa, Antoni
core
Whether Patients With Stage Ⅱ/Ⅲ Colorectal Cancer Benefit From Adjuvant Chemotherapy: A Modeling Analysis of Literature Aggregate Data. [PDF]
Front Pharmacol, 2022 Zha S, Li T, Zheng Q, Li L.
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