Results 111 to 120 of about 174,204,952 (254)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Exploring the Correlation Between the Systemic Immune Inflammation Index (SII), Systemic Inflammatory Response Index (SIRI), and Type 2 Diabetic Retinopathy

, 2023
Shuqi Wang,1,2 Xiaoyu Pan,1,2 Boying Jia,1,2 Shuchun Chen1,2 1Department of Internal Medicine, Hebei Medical University, Shijiazhuang, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhuang, People’s Republic of ...
Pan X, Wang S, Jia B, Chen S
core  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Associations Between Systemic Immunity Inflammation Index, Aggregate Index of Systemic Inflammation, and Hospital Acquired Otitis Media in Children Aged ≤12 years with Bacterial Pneumonia

Infection and Drug Resistance
Liyuan Han,1,2 Yanhua Li,1,2 Chunyan Gao,1,2 Jie Liu,3 Jinghua Wu1,2 1Clinical Laboratory, Tangshan Maternal and Child Health Care Hospital, Tangshan, Hebei, People’s Republic of China; 2Key Laboratory of Molecular Medicine for Abnormal Development and ...
Han L, Li Y, Gao C, Liu J, Wu J
doaj  

Is it possible to use complete blood collection based systemic inflammatory indices as potential biomarkers for chronic spontaneous urticaria

Frontiers in Immunology
Chronic spontaneous urticaria (CSU) is mediated not only by mast cells but also by eosinophils and basophils. We evaluated whether complete blood collection based systemic inflammatory indices- including the systemic immune-inflammation index (SII ...
Bingyu Li, Bingyu Li, Lu Peng, Lu Peng, Runqing Li, Mai Shi, Mai Shi, Yingyi Li, Yingyi Li, Chinghsuan Sun, Chinghsuan Sun, Zhuying Zhang, Zhuying Zhang, Jingwen Xue, Jingwen Xue, Yi Zhao, Yi Zhao   +16 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Computed tomography-based association of hematological parameters and systemic inflammation markers with COVID-19 severity in hospitalized patients

Инфекция и иммунитет
Laboratory data are important for confirming diagnosis, assessing COVID-19 progression, and determining treatment measures. The aim of this study was to evaluate the associations of hematological, coagulation parameters, and systemic inflammatory markers
Marina E. Dyakova, A. V. Makarova, O. L. Rubtsova, D. S. Esmedlyaeva, P. K. Yablonskiy   +4 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Early dynamic changes in inflammatory indices and their association with mortality in intermediate–high and high-risk pulmonary embolism patients admitted to the ICU: a retrospective observational cohort study

European Journal of Medical Research
Objective Acute pulmonary embolism (PE) is associated with high mortality, particularly in patients requiring intensive care unit (ICU) management. This study aimed to evaluate early dynamic changes in systemic inflammatory indices and their association ...
Ayşe Çapar, Şeyma Başlılar
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source