Results 61 to 70 of about 1,266 (235)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Interfaz entre el plan de producción y el programa de producción en ambientes de ensamble Interface between the production plan and the master production schedule in assembly environments

Tecnología en Marcha, 2012
En un entorno de producción existe una relación directa entre el mercado y los procesos de manufactura de los bienes. Sin embargo, cuando la producción está inmersa en un ambiente de ensamble, el procedimiento de la planificación y la programación se ...
Marcos Moya Navarro, Magaly Sánchez Brenes   +1 more
doaj  

Production planning of biopharmaceutical manufacture.

, 2006
Multiproduct manufacturing facilities running on a campaign basis are increasingly becoming the norm for biopharmaceuticals, owing to high risks of clinical failure, regulatory pressures and the increasing number of therapeutics in clinical evaluation ...
Lakhdar, K.
core  

Work-in-process clearing in supply chain operations planning

, 2008
In this study we provide insights into the effectiveness of the clearing function concept in a hierarchical planning context. The clearing function is a mathematical representation of the relation between the Work-In-Process (WIP) and the throughput of a
Fransoo, JC Jan, Fransoo, J.C.; id_orcid, Selcuk, B Baris, Kok, AG Ton de, Selcuk, B., Fransoo, J.C., Kok, de, A.G., Kok, de, A.G.; id_orcid   +7 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

A hierarchical approach to multi-project planning under uncertainty. [PDF]

We survey several viewpoints on the management of the planning complexity of multi-project organisations under uncertainty. A positioning framework is proposed to distinguish between different types of project-driven organisations, which is meant to aid ...
Wullink, G, Hans, EW, Herroelen, Willy, Leus, Roel   +3 more
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A multilevel integrative approach to hospital case mix and capacity planning. [PDF]

Hospital case mix and capacity planning involves the decision making both on patient volumes that can be taken care of at a hospital and on resource requirements and capacity management.
Demeulemeester, Erik, Ma, Guoxuan
core  

Integrated planning and scheduling for precast concrete production

, 2007
In the research, an integrated planning and scheduling model, IPSMPP, is established for make-to-order precast production using a comprehensive casting organization.
Zhai, Xiaofeng
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source