Results 141 to 150 of about 134,524 (260)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Divergent Soil Aggregate Stability Despite Similar Organic Carbon Gains Under Long-Term Maize Intercropping with Different Legume Cover Crops. [PDF]

Microorganisms
Zhou T, Pan D, Zhou Y, Li D, Xu J, Xuan Z, Deng J, Zhang J, Zhao B.   +8 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Vegetation restoration increases soil aggregate stability and aggregate-associated black carbon content in a karst rocky desertification area in southwestern Guangxi. [PDF]

Front Plant Sci
Chu J, Huang K, Teng Q, Shen Y, Sun Y, Zhang D, Xu G, Ding T, Huang L, Tan Z, Luo Y.   +10 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Ecological Modules Link Soil Aggregate Stability, Chemical Properties and Fungal Communities Under Plant Species-Based Revegetation. [PDF]

Environ Microbiol Rep
Ding Z, Li J, Bai L.
europepmc   +1 more source

Assessing soil degradation under land-use change: insight from soil erosion and soil aggregate stability in a small karst catchment in southwest China. [PDF]

PeerJ, 2020
Liu M, Han G.
europepmc   +1 more source

Stability of Aggregates and the Processes that Help in Their Formation and Stabilization [PDF]

International Journal of Plant & Soil Science, 2018
Andréia Schiller, Jéssica Manfrin, Daniele Eckhardt, Edleusa Seidel, Maria Lana, Affonso Jr, Marinez Sampaio, Carlos Rego   +7 more
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The impact of soil acidification on cementing substances and aggregate stability. [PDF]

PLoS One
Zhu X, Zhao S, Lin S, Wang J, Leng S.
europepmc   +1 more source