Results 191 to 200 of about 4,583,324 (336)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Author Correction: Response of soil organic carbon and soil aggregate stability to changes in land use patterns on the Loess Plateau. [PDF]

Sci Rep
Pan Z, Cai X, Bo Y, Guan C, Cai L, Haider FU, Li X, Yu H.   +7 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Changes of soil organic carbon and aggregate stability along elevation gradient in Cunninghamia lanceolata plantations. [PDF]

Sci Rep
Cao X, Xu Y, Wang F, Zhang Z, Xu X.
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

<i>Bacillus tropicus</i> YJ33 and <i>Medicago sativa</i> L. Synergistically Enhance Soil Aggregate Stability in Saline-Alkali Environments. [PDF]

Microorganisms
Li J, Che Y, Chen S, Liu M, Diao M, Yang C, Jia W.   +6 more
europepmc   +1 more source

Colloidal Drug Aggregate Stability in High Serum Conditions and Pharmacokinetic Consequence. [PDF]

ACS Chem Biol, 2019
Ganesh AN, Aman A, Logie J, Barthel BL, Cogan P, Al-Awar R, Koch TH, Shoichet BK, Shoichet MS.   +8 more
europepmc   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Response of soil organic carbon and soil aggregate stability to changes in land use patterns on the Loess Plateau. [PDF]

Sci Rep
Pan Z, Cai X, Bo Y, Guan C, Cai L, Haider FU, Li X, Yu H.   +7 more
europepmc   +1 more source

Effects of Biochar Combined with Nitrogen Fertilizer Reduction on Rapeseed Yield and Soil Aggregate Stability in Upland of Purple Soils. [PDF]

Int J Environ Res Public Health, 2019
Tian X, Li Z, Wang L, Wang Y, Li B, Duan M, Liu B.   +6 more
europepmc   +1 more source