Results 111 to 120 of about 2,756,148 (249)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Aggregate stability impacts important soil functions, including carbon/water storage and soil structure. Macroaggregate stability tests, using rainfall simulation or wet sieving, are commonly used, but microaggregate stability tests may be more ...
Yaslin N. Gonzalez +3 more
doaj +1 more source
Soil aggregates are critical determinants of soil erosion resistance and nutrient retention capacity, while freeze–thaw cycles (FTCs) induce the structural reorganization of soil aggregates, thereby altering soil stability and influencing soil organic ...
Yuting Cheng +5 more
doaj +1 more source
Variability of aggregate stability and surface crusting in Zimbabwe
Soil surface samples were collected from several transects in intensively cultivated 'crusting soil' (chromic luvisol) areas in Zimbabwe. The aggregate stability was assessed by measuring particle size distribution after various breakdown treatments and ...
Le Bissonnais Y +3 more
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Preferential flow is a common heterogeneous phenomenon of movement of water and solute in soil. However, the difference of soil aggregate stability between preferential flow domain and matrix flow domain are still unclear.
REN Zeying +6 more
doaj
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Aggregate Price Shocks and Financial Stability: The United Kingdom 1796-1999 [PDF]
This paper investigates the impact historically of aggregate price shocks on financial stability in the United Kingdom. We construct an annual index of U.K.
Michael D. Bordo +2 more
core +2 more sources
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source

