Results 101 to 110 of about 2,751,097 (299)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Aggregate price shocks and financial instability: a historical analysis [PDF]

This paper presents empirical evidence on the hypothesis that aggregate price disturbances cause or worsen financial distress. We construct two annual indexes of financial conditions for the United States covering 1790-1997, and estimate the effect of ...
Michael D. Bordo, Michael J. Dueker, David C. Wheelock   +2 more
core  

Dataset for the manuscript "Land use and soil property effects on aggregate stability assessed by three different slaking methods"

This dataset was used in the research article "Land use and soil property effects on aggregate stability assessed by three different slaking methods" as published in European Journal of Soil Science by Poeplau et al..
Poeplau, Christopher
core   +1 more source

Influence of aggregate gradation on hma mixes stability

Romanian Journal of Transport Infrastructure, 2015
The load transfer capacity of pavements is to a great extend influenced by aggregates. About 85% of the total volume of hot mix asphalt (HMA) mixtures consists of aggregates; thus, they are greatly influenced by aggregate properties like angularity ...
Kalaitzaki Elvira, Kollaros George, Athanasopoulou Antonia   +2 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Divergent responses of aggregate breakdown by slaking to nitrogen forms in solution for contrasting soil types

Geoderma
Aggregate stability strongly affects many soil processes and is critical to maintain sustainable agriculture. Aggregate breakdown is controlled by the interaction between soil intrinsic properties and solution characteristics.
Xinliang Wu, Chenyu Wang, Chongfa Cai, Sixu Yao, Jinxing Zhou   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

An energy‐based aggregate stability method is more management‐sensitive than commercial methods in coarse‐textured, subtropical orchard soils

Agricultural & Environmental Letters
Aggregate stability impacts important soil functions, including carbon/water storage and soil structure. Macroaggregate stability tests, using rainfall simulation or wet sieving, are commonly used, but microaggregate stability tests may be more ...
Yaslin N. Gonzalez, Allan R. Bacon, Sarah L. Strauss, Gabriel Maltais‐Landry   +3 more
doaj   +1 more source