Results 151 to 160 of about 5,001,808 (350)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Effects of Long-Term Elevated CO₂ on Soil Aggregate Structure and Microbial Communities in a Deyeuxia angustifolia Wetland of the Sanjiang Plain

Microorganisms
To investigate the effects of long-term elevated atmospheric CO2 (eCO2) on the distribution and stability of soil aggregates and microbial characteristics in wetland soils and to reveal the mechanisms by which eCO2 influences soil organic carbon (SOC ...
Lanying Shi, Hongjie Cao, Rongtao Zhang, Haixiu Zhong, Yingnan Liu, Jifeng Wang, Donglai Zhang, Lin Li, Hongwei Ni   +8 more
doaj   +1 more source

Predicting Money Multiplier in Pakistan [PDF]

The paper has developed time-series models for the monthly money multiplier and its components, viz., currency-deposit ratio, reserve-deposit ratio, etc.
Muhammad Farooq Arby
core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Effects of Different Reclamation Methods on Soil Aggregate Cementing Agents and Potential Aggregate Formation Mechanisms

Agriculture
Iron ore tailings have been shown to promote the formation of soil aggregate cementing agents through weathering, thereby influencing soil aggregate formation in reclaimed land.
Zhichao Dong, Zhongxiu Sun, Zhenxing Bian, Wenjuan Jin, Yuhan Qiu, Chuqiao Wang, Deyang Guan, Yufei Zhang, Mingzhe Han   +8 more
doaj   +1 more source

Studi Pemanfaatan Agregat Sungai dan Debu Batu sebagai Agregat Halus pada Campuran Hrs-wc [PDF]

, 2016
The purpose of this study is to find the effect of characteristics Marshall test that use of two different aggregate in asphalt mixture HRS-WC and comparing both types of smooth aggregate on the strength of asphalt mixture.
Alfian, I. (Ifan), Sulandari, E. (Eti), Mayuni, S. (Siti)   +2 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Aggregate stability under a budget rule and labor mobility. [PDF]

Econ Model, 2020
Micheli M.
europepmc   +1 more source