Results 131 to 140 of about 135,712 (261)

Re-acidification of limed soil alters aggregate stability and soil carbon turnover in an agroecosystem. [PDF]

RSC Adv
Hamza A, Karčauskienė D, Mockevičienė I, Repšienė R, Noor-Us-Sabah, Šlepetienė A.   +5 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Divergent Soil Aggregate Stability Despite Similar Organic Carbon Gains Under Long-Term Maize Intercropping with Different Legume Cover Crops. [PDF]

Microorganisms
Zhou T, Pan D, Zhou Y, Li D, Xu J, Xuan Z, Deng J, Zhang J, Zhao B.   +8 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Vegetation restoration increases soil aggregate stability and aggregate-associated black carbon content in a karst rocky desertification area in southwestern Guangxi. [PDF]

Front Plant Sci
Chu J, Huang K, Teng Q, Shen Y, Sun Y, Zhang D, Xu G, Ding T, Huang L, Tan Z, Luo Y.   +10 more
europepmc   +1 more source

Stability of Aggregates and the Processes that Help in Their Formation and Stabilization [PDF]

International Journal of Plant & Soil Science, 2018
Andréia Schiller, Jéssica Manfrin, Daniele Eckhardt, Edleusa Seidel, Maria Lana, Affonso Jr, Marinez Sampaio, Carlos Rego   +7 more
openaire   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Ecological Modules Link Soil Aggregate Stability, Chemical Properties and Fungal Communities Under Plant Species-Based Revegetation. [PDF]

Environ Microbiol Rep
Ding Z, Li J, Bai L.
europepmc   +1 more source

Assessing soil degradation under land-use change: insight from soil erosion and soil aggregate stability in a small karst catchment in southwest China. [PDF]

PeerJ, 2020
Liu M, Han G.
europepmc   +1 more source