Results 41 to 50 of about 201,256 (259)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Regulating the proximity effect of heterocycle-containing AIEgens

Nature Communications, 2023
Proximity effect, which refers to the low-lying (n,π*) and (π,π*) states with close energy levels, usually plays a negative role in the luminescent behaviors of heterocyclic luminogens.
Jianyu Zhang, Yujie Tu, Hanchen Shen, Jacky W. Y. Lam, Jianwei Sun, Haoke Zhang, Ben Zhong Tang   +6 more
doaj   +1 more source

A general perspective of the characterization and quantification of nanoparticles: Imaging, spectroscopic, and separation techniques [PDF]

, 2014
This article gives an overview of the different techniques used to identify, characterize, and quantify engineered nanoparticles (ENPs). The state-of-the-art of the field is summarized, and the different characterization techniques have been grouped ...
Anderson de la LLana, S., Anderson, I.S., Capitán Vallvey, L. F., Cecchini, R., Costa Fernández, J.M., Domínguez Meister, Santiago, Lapresta Fernández, A., Marco, María Pilar, Moreno Bondi, M.C., Salinas Castillo, A., Sánchez López, J.C.   +10 more
core   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers [PDF]

, 2019
© The Royal Society of Chemistry 2019.Synthetic glycopolymers are increasingly investigated as multivalent ligands for a range of biological and biomedical applications.
Fernandez-Trillo, F., Foralosso, R., He, Y., King, P.J.S., Laughton, C. A., Madeira do O, J., Mantovani, G., Mastrotto, F., Stolnik, S., Styliari, Ioanna Danai, van der Walle, C.F., Xerri, R.M., Yilmaz, G.   +12 more
core   +4 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Photo‐induced Bacillus subtilis‐spore transformation for bowel disease therapy and therapeutic outcome visualization

Aggregate
Efficient strategies for transforming Bacillus subtilis vegetative cells into spores (BtS transformation) are still limited, although they show promise for the treatment of inflammatory bowel disease (IBD).
Lin Kong, Wei He, Junyi Gong, Zijie Qiu, Zheng Zhao, Ben Zhong Tang   +5 more
doaj   +1 more source

Formation and destruction of polycyclic aromatic hydrocarbon clusters in the interstellar medium [PDF]

, 2006
The competition between the formation and destruction of coronene clusters under interstellar conditions is investigated theoretically. The unimolecular nucleation of neutral clusters is simulated with an atomic model combining an explicit classical ...
Allamandola, Allamandola, Barker, Bauschlicher, Benharash, Bernard, Beyer, Boulanger, Bouvier, Bréchignac, C. Joblin, Calvo, Cesarsky, Chesnavich, D. Toublanc, F. Calvo, F. Spiegelman, Fuente, Fuente, Gillespie, Gonzales, Grimme, Herbst, Hudgins, Joblin, Joblin, Klots, Kurucz, Le Bourlot, Lemaire, Li, Léger, M. Rapacioli, Martin, Marzec, Miller, Neirotti, P. Parneix, Piuzzi, Rapacioli, Rapacioli, Schmidt, Sofia, Song, Valenti, van de Waal, van den Ancker, Van Oanh, Weerasinghe, Witt   +49 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source