Results 71 to 80 of about 201,256 (259)

Confinement‐Enhanced Ultrabright AIE Nanoparticles With Broad Emission for Ultrasensitive Lateral Flow Immunoassay

Aggregate
Fluorescent lateral flow immunoassay (LFIA) has emerged as a critical point‐of‐care (POC) diagnostic platform for in vitro diagnosis. However, the analytical sensitivity of conventional fluorescent LFIA is constrained by the suboptimal quantum yield (QY)
Yaxin Hu, Li Xie, Lidan Chen, Zhaohui Sun, Rong Hu, Zhiming Wang, Ben Zhong Tang   +6 more
doaj   +1 more source

An AIE fungal vacuole membrane probe toward species differentiation, vacuole formation visualization, and targeted photodynamic therapy

Materials Today Bio
Vacuoles are unique organelles of fungi. The development of probes targeting the vacuoles membrane will enable visualization of physiological processes and precise diagnosis and therapy.
Bingnan Wang, Siyuan Wang, Chunyang Li, Jianqing Li, Meixi Yi, Jing-Wen Lyu, Bing Gu, Ryan T.K. Kwok, Jacky W.Y. Lam, Anjun Qin, Ben Zhong Tang   +10 more
doaj   +1 more source

Mass Spectrometric Characterization of Oligomers in Pseudomonas aeruginosa Azurin Solutions [PDF]

, 2011
We have employed laser-induced liquid bead ion desorption mass spectroscopy (LILBID MS) to study the solution behavior of Pseudomonas aeruginosa azurin as well as two mutants and corresponding Re-labeled derivatives containing a Re(CO)_(3)(4,7-dimethyl-1,
Brutschy, Bernd, Gray, Harry B., Hof, Martin, Soklová, Lucie, Sýkora, Jan, Vlček, Antonín, Jr., Williamson, Heather   +6 more
core   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Understanding the AIE phenomenon of nonconjugated rhodamine derivatives via aggregation-induced molecular conformation change

Nature Communications
The bottom-up molecular science research paradigm has greatly propelled the advancement of materials science. However, some organic molecules can exhibit markedly different properties upon aggregation.
Lin-Lin Yang, Haoran Wang, Jianyu Zhang, Bo Wu, Qiyao Li, Jie-Ying Chen, A-Ling Tang, Jacky W. Y. Lam, Zheng Zhao, Song Yang, Ben Zhong Tang   +10 more
doaj   +1 more source

Organic luminescent materials: The concentration on aggregates from aggregation‐induced emission

Aggregate, 2020
The research of organic luminescent materials in aggregate has drawn more and more attention for their wide applications. To adjust the luminescent properties for aggregates, a deep understanding of the corresponding internal mechanism is needed. In this
Jie Yang, Manman Fang, Zhen Li
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Ru@NiMoS aggregate with boosted electrochemical catalysis for enhanced electrochemiluminescence and lidocaine detection

Smart Molecules
A binder‐free Ru@NiMoS electrode was engineered by in situ growth of two‐dimensional NiMoS nanosheets on nickel foam. This process effectively promoted the electrostatic‐driven aggregation of Ru(bpy)32+, harnessing the synergistic effect to enhance ...
Yongzhuang Lu, Haoran Wang, Qiyao Li, Qian Liu, Xiaoxu Zhang, Yuying Jia, Xiangyu Cai, Zheng Zhao, Yanfu Huan, Ben Zhong Tang   +9 more
doaj   +1 more source

Photoionizaton of Pure and Doped Helium Nanodroplets

, 2014
Helium nanodroplets, commonly regarded as the "nearly ideal spectroscopic matrix", are being actively studied for more than two decades now. While they mostly serve as cold, weakly perturbing and transparent medium for high-resolution spectroscopy of ...
Mudrich, M., Stienkemeier, F.
core   +1 more source

Dust Emissivity Variations In the Milky Way [PDF]

, 2009
Dust properties appear to vary according to the environment in which the dust evolves. Previous observational indications of these variations in the FIR and submm spectral range are scarce and limited to specific regions of the sky.
Abergel, Abergel, Allamandola, Bacmann, Bazell, Bennett, Bernard, Boulanger, Boulanger, C. Mény, Cambrésy, Cambrésy, Cambrésy, Caselli, D. Paradis, Dale, Dame, Delabrouille, Dickey, Draine, Draine, Dupac, Désert, Finkbeiner, Fixsen, Fixsen, J.-Ph. Bernard, Kemper, Lagache, Laureijs, Laureijs, Laureijs, Macias-Perez, Magnani, Mathis, Mény, Puget, Stepnik, Stepnik, Strong, Tielens, Tielens, Tristram, Van de Bult   +43 more
core   +3 more sources