Results 71 to 80 of about 201,780 (239)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Confinement‐Enhanced Ultrabright AIE Nanoparticles With Broad Emission for Ultrasensitive Lateral Flow Immunoassay

Aggregate
Fluorescent lateral flow immunoassay (LFIA) has emerged as a critical point‐of‐care (POC) diagnostic platform for in vitro diagnosis. However, the analytical sensitivity of conventional fluorescent LFIA is constrained by the suboptimal quantum yield (QY)
Yaxin Hu, Li Xie, Lidan Chen, Zhaohui Sun, Rong Hu, Zhiming Wang, Ben Zhong Tang   +6 more
doaj   +1 more source

An AIE fungal vacuole membrane probe toward species differentiation, vacuole formation visualization, and targeted photodynamic therapy

Materials Today Bio
Vacuoles are unique organelles of fungi. The development of probes targeting the vacuoles membrane will enable visualization of physiological processes and precise diagnosis and therapy.
Bingnan Wang, Siyuan Wang, Chunyang Li, Jianqing Li, Meixi Yi, Jing-Wen Lyu, Bing Gu, Ryan T.K. Kwok, Jacky W.Y. Lam, Anjun Qin, Ben Zhong Tang   +10 more
doaj   +1 more source

Formation and destruction of polycyclic aromatic hydrocarbon clusters in the interstellar medium [PDF]

, 2006
The competition between the formation and destruction of coronene clusters under interstellar conditions is investigated theoretically. The unimolecular nucleation of neutral clusters is simulated with an atomic model combining an explicit classical ...
Allamandola, Allamandola, Barker, Bauschlicher, Benharash, Bernard, Beyer, Boulanger, Bouvier, Bréchignac, C. Joblin, Calvo, Cesarsky, Chesnavich, D. Toublanc, F. Calvo, F. Spiegelman, Fuente, Fuente, Gillespie, Gonzales, Grimme, Herbst, Hudgins, Joblin, Joblin, Klots, Kurucz, Le Bourlot, Lemaire, Li, Léger, M. Rapacioli, Martin, Marzec, Miller, Neirotti, P. Parneix, Piuzzi, Rapacioli, Rapacioli, Schmidt, Sofia, Song, Valenti, van de Waal, van den Ancker, Van Oanh, Weerasinghe, Witt   +49 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Understanding the AIE phenomenon of nonconjugated rhodamine derivatives via aggregation-induced molecular conformation change

Nature Communications
The bottom-up molecular science research paradigm has greatly propelled the advancement of materials science. However, some organic molecules can exhibit markedly different properties upon aggregation.
Lin-Lin Yang, Haoran Wang, Jianyu Zhang, Bo Wu, Qiyao Li, Jie-Ying Chen, A-Ling Tang, Jacky W. Y. Lam, Zheng Zhao, Song Yang, Ben Zhong Tang   +10 more
doaj   +1 more source

Organic luminescent materials: The concentration on aggregates from aggregation‐induced emission

Aggregate, 2020
The research of organic luminescent materials in aggregate has drawn more and more attention for their wide applications. To adjust the luminescent properties for aggregates, a deep understanding of the corresponding internal mechanism is needed. In this
Jie Yang, Manman Fang, Zhen Li
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Ru@NiMoS aggregate with boosted electrochemical catalysis for enhanced electrochemiluminescence and lidocaine detection

Smart Molecules
A binder‐free Ru@NiMoS electrode was engineered by in situ growth of two‐dimensional NiMoS nanosheets on nickel foam. This process effectively promoted the electrostatic‐driven aggregation of Ru(bpy)32+, harnessing the synergistic effect to enhance ...
Yongzhuang Lu, Haoran Wang, Qiyao Li, Qian Liu, Xiaoxu Zhang, Yuying Jia, Xiangyu Cai, Zheng Zhao, Yanfu Huan, Ben Zhong Tang   +9 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source