Results 91 to 100 of about 671,156 (267)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
An Event‐Driven Retinomorphic Photodiode
SmartMatCompared with traditional frame‐based machine vision sensors, event cameras are regarded as a promising direction for the next generation of visual systems, thanks to their low latency, minimal data redundancy, and high temporal responsiveness in dynamic
Yilin Zhao, Deyang Ji
doaj +1 more source
Age-Dependent Protein Aggregation Initiates Amyloid-β Aggregation
Frontiers in Aging Neuroscience, 2017 Aging is the most important risk factor for neurodegenerative diseases associated with pathological protein aggregation such as Alzheimer’s disease.
Nicole Groh +9 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Wearable Sensors Based on Stretchable Organic Transistors
SmartMatOrganic electrochemical transistors (OECTs) hold potential for in‐sensor computing and wearable healthcare systems. Nevertheless, their inherent limitations in stretchability and conformability hinder their scalability and practical deployment.
Yang Liu, Deyang Ji
doaj +1 more source
Modus Tollens in the Setting of Discrete Uninorms
AxiomsThis study focuses on the Modus Tollens (MT) property induced by discrete uninorms. Specifically, we identify the set of necessary and sufficient criteria for a discrete implication function to comply with this logical property. This rule of inference is
Isabel Aguiló +2 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source