Results 101 to 110 of about 671,156 (267)

Selective structural transformation of metal-organic frameworks for hydrogenation reaction

Nano Research
The structure transformation of metal-organic frameworks (MOFs) is significant for expanding the MOF family and exploring new MOF properties; however, it remains a significant challenge.
Yue Wan, Meina Song, Qingyun Zhang, Shaopeng Li, Aijie Ma, Hong Wang, Jun Guo, Zhifang Wang, Bingqing Wang, Meiting Zhao   +9 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

EXPLORING A NEUROPROTECTIVE ROLE FOR REST IN PARKINSON’S DISEASE IN VIVO

IBRO Neuroscience Reports, 2023
Dalila Ciceri, Begum Kurt, Patricia Villegas-Zafra, Jon Olano-Bringas, Nora Bengoa-Vergniory   +4 more
doaj   +1 more source

Enzymatically catalyzed molecular aggregation

Nature Communications
The dynamic modulation of the aggregation process of small molecules represents an important research objective for scientists. However, the complex and dynamic nature of internal environments in vivo impedes controllable aggregation processes of single ...
Wen-Jin Wang, Rongyuan Zhang, Liping Zhang, Liang Hao, Xu-Min Cai, Qian Wu, Zijie Qiu, Ruijuan Han, Jing Feng, Shaojuan Wang, Parvej Alam, Guoqing Zhang, Zheng Zhao, Ben Zhong Tang   +13 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

To aggregate or not to aggregate… [PDF]

Journal of Thrombosis and Haemostasis, 2007
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

IS HSP70 A THERAPEUTIC TARGET FOR PARKINSON'S DISEASE?

IBRO Neuroscience Reports, 2023
Jon Olano-Bringas, Patricia Villegas-Zafra, Begum Kurt, Dalila Ciceri, Arturo Muga, Nora Bengoa-Vergniory   +5 more
doaj   +1 more source