Results 131 to 140 of about 2,239,330 (392)

Breaking the Expressive Bottlenecks of Graph Neural Networks [PDF]

arXiv, 2020
Recently, the Weisfeiler-Lehman (WL) graph isomorphism test was used to measure the expressiveness of graph neural networks (GNNs), showing that the neighborhood aggregation GNNs were at most as powerful as 1-WL test in distinguishing graph structures. There were also improvements proposed in analogy to $k$-WL test ($k>1$).
arxiv  

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

An Introductory Course to Judgment Aggregation [PDF]

arXiv, 2016
Reaching some form of consensus is often necessary for autonomous agents that want to coordinate their actions or otherwise engage in joint activities. One way to reach a consensus is by aggregating individual information, such as decisions, beliefs, preferences and constraints.
arxiv  

Hydrophobic carbon dots with blue dispersed emission and red aggregation-induced emission

Nature Communications, 2019
Carbon dots (CDs) have been studied for years as one of the most promising fluorescent nanomaterials. However, CDs with red or solid-state fluorescence are rarely reported.
Haiyao Yang, Yingliang Liu, Zhouyi Guo, B. Lei, J. Zhuang, Xuejie Zhang, Zhiming Liu, Chaofan Hu   +7 more
semanticscholar   +1 more source

Cytoplasmic delivery of antibodies through grafting a functional single complementarity‐determining region loop

FEBS Letters, EarlyView.
We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon, Juho Choi, Youngin Roh, Eunbin Lee, Luigie Villamante, Myung‐Hee Kwon   +5 more
wiley   +1 more source

Participation of an Energy Storage Aggregator in Electricity Markets [PDF]

arXiv, 2017
An important function of aggregators is to enable the participation of small energy storage units in electricity markets. This paper studies two generally overlooked aspects related to aggregators of energy storage: i) the relationship between the aggregator and its constituent storage units and ii) the aggregator's effect on system welfare.
arxiv  

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

A Class of Practical and Acceptable Social Welfare Orderings That Satisfy the Principles of Aggregation and Non-Aggregation: Reexamination of the Tyrannies of Aggregation and Non-Aggregation [PDF]

arXiv
This paper revisits impossibility results on the tyrannies of aggregation and non-aggregation. I propose two aggregation principles (quantitative aggregation and ratio aggregation) and investigate theoretical implications. As a result, I show that quantitative aggregation and minimal non-aggregation are incompatible while ratio aggregation and minimal ...
arxiv  

The Effect of Dispersal during the Pre-epidemic Stage, and of subsequent Re-aggregation [PDF]

, 1922
W. W. C. Topley
openalex   +1 more source