Results 211 to 220 of about 673,648 (266)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Epigenetic Evidence Implies Disturbed Proteostasis and Potentially Protein Aggregation in Suicidality. [PDF]

open access: yesBiomolecules
Šmon J   +7 more
europepmc   +1 more source

Unveiling the Role of Alkyl Chain in Boosting Antibacterial Selectivity and Cell Biocompatibility

open access: yesJACS Au
Ziwei Deng   +11 more
doaj   +1 more source

The chaperone DNAJB6b halts amyloid formation through association with transient Aβ oligomers.

open access: yesPhys Chem Chem Phys
Getachew J   +5 more
europepmc   +1 more source

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