Results 281 to 290 of about 1,974,144 (325)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Developing an artificial intelligence-generated peptide targeting platelet-type von Willebrand disease. [PDF]

Blood Adv
Kazmirchuk TDD, Wang J, Bury L, Falcinelli E, Bradbury-Jost C, Koziar A, Al-Gafari M, Takallou S, Willmore WG, Dehne F, Gresele P, Othman M, Golshani A.   +12 more
europepmc   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Self-aggregating Lactiplantibacillus plantarum enhances type-I interferon responses via the cytosolic sensors NOD2 and cGAS. [PDF]

Gut Microbes
Solis S, Maldonado EM, Mukhopadhyay S, Jan G, Landete JM, Maluquer de Motes C, Gutierrez-Merino J.   +6 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Critical impact of automobile industry with advanced decision support system and Aczél-Alsina Hammy mean operators. [PDF]

Sci Rep
Hussain A, Ullah K, Ali Z, Pamucar D.
europepmc   +1 more source

Planktonic Aggregation Enhances Antibiotic Tolerance in Non-MDR Acinetobacter baumannii. [PDF]

Microorganisms
Liu J, Li Y, Liu J, Tao Z, Lu F, Tian F, Han JH, He X.   +7 more
europepmc   +1 more source

Unveiling the Role of Alkyl Chain in Boosting Antibacterial Selectivity and Cell Biocompatibility

JACS Au
Ziwei Deng, Rongyuan Zhang, Junyi Gong, Zicong Zhang, Lingyan Zhang, Zijie Qiu, Parvej Alam, Jianquan Zhang, Yong Liu, Ying Li, Zheng Zhao, Ben Zhong Tang   +11 more
doaj   +1 more source

Privacy-Preserving Collaborative Diabetes Prediction in Heterogeneous Health Care Systems: Algorithm Development and Validation of a Secure Federated Ensemble Framework. [PDF]

JMIR Diabetes
Hasan MR, Li J.
europepmc   +1 more source