Results 111 to 120 of about 51,126 (300)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Scanner Data, Time Aggregation and the Construction of Price Indexes [PDF]
The impact of weekly, monthly and quarterly time aggregation on estimates of price change is examined for nineteen different supermarket item categories over a fifteen month period using scanner data.
Ivancic, Lorraine +2 more
core
Dynamic Correlation between Platelet Aggregation and Inflammatory-like State in Athlete Horses
Applied SciencesThis study aimed to assess the effect of exercise on serum electrophoretic protein pattern, C-reactive protein (CRP) and platelet aggregation in horses subjected to a jumping exercise.
Francesca Arfuso +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
International Real Estate Diversification: Empirical Tests using Hedged Indices [PDF]
This study examines the potential diversification opportunities arising from the extension of real estate portfolios into an international environment.
Simon Stevenson
core
Structure and performance study of ad hoc microsat constellation with secondary launches
Advances in Mechanical Engineering, 2016 In this article, an ad hoc microsat constellation based on secondary launches is proposed to meet the demands for the constellation characteristics. Research on its structural design and characteristics is carried out. First, constellation characteristic
Guan Xin, Hua Bing, Wu Yunhua
doaj +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Aggregation of exponential smoothing processes with an application to portfolio risk evaluation [PDF]
In this paper we propose a unified framework to analyse contemporaneous and temporal aggregation of exponential smoothing (EWMA) models. Focusing on a vector IMA(1,1) model, we obtain a closed form representation for the parameters of the ...
SBRANA, Giacomo, SILVESTRINI, Andrea
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source