Results 151 to 160 of about 1,658,789 (343)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Visibility Graph Power Geometric Aggregation Operator and Its Application in Water, Energy, and Food Efficiency Evaluation. [PDF]

Int J Environ Res Public Health, 2020
Liu L, Huang J, Wang H.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Modular relaxed indistinguishability and the aggregation problem

AIMS Mathematics
The notion of indistinguishability operator plays a central role in a large number of problems that arise naturally in decision-making, artificial intelligence, and computer science. Among the different issues studied for these operators, the aggregation
M. D. M. Bibiloni-Femenias, O. Valero
doaj   +1 more source

Aggregation Operators and Ruled Surfaces

, 2008
Aggregation operators in two variables that are ruled quadric surfaces are studied.
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Bipolar Neutrosophic Dombi-Based Heronian Mean Operators and Their Application in Multi-criteria Decision-Making Problems

International Journal of Computational Intelligence Systems
Dombi operations based on the Dombi t-norm (TN) and t-conorm (TCN) have the advantage in terms of operational parameter flexibility in dealing with varying degrees of uncertainty and aggregation requirements.
Siti Nurhidayah Yaacob, Hazwani Hashim, Noor Azzah Awang, Nor Hashimah Sulaiman, Ashraf Al-Quran, Lazim Abdullah   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Picture Fuzzy Einstein Hybrid-Weighted Aggregation Operator and Its Application to Multicriteria Group Decision Making.

Comput Intell Neurosci, 2022
Cao G.
europepmc   +1 more source

Belief merging within fragments of propositional logic

, 2014
Recently, belief change within the framework of fragments of propositional logic has gained increasing attention. Previous works focused on belief contraction and belief revision on the Horn fragment.
Creignou, Nadia, Papini, Odile, Rümmele, Stefan, Woltran, Stefan   +3 more
core   +1 more source