Results 51 to 60 of about 14,621 (261)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A Novel Multi-Criteria Group Decision-Making Approach Based on Bonferroni and Heronian Mean Operators under Hesitant 2-Tuple Linguistic Environment

Mathematics, 2021
Ambiguous and uncertain facts can be handled using a hesitant 2-tuple linguistic set (H2TLS), an important expansion of the 2-tuple linguistic set. The vagueness and uncertainty of data can be grabbed by using aggregation operators.
Shahzad Faizi, Wojciech Sałabun, Nisbha Shaheen, Atiq ur Rehman, Jarosław Wątróbski   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Generalized Cubic Aggregation Operators with Application in Decision Making Problem

Journal of New Theory, 2018
There are many aggregation operators and their applications have been developed up to date, but in this paper we introduced the idea of generalized aggregation operator.
Muhammad Shakeel, Saleem Abdullah, Aliya Fahmi   +2 more
doaj  

Dombi aggregation operator in terms of complex bipolar fuzzy sets with application in decision making problems

Complex & Intelligent Systems
The complex bipolar fuzzy sets fundamentally expand upon bipolar fuzzy sets and complex fuzzy set, and demonstrate efficacy in dealing with two-dimensional uncertainty, specifically where amplitude and phase information are both relevant.
Naveed Yaqoob, Muhammad Gulistan, Muhammad Mohsin Abbas, Khizar Hayat, Mohammed M. Al-Shamiri   +4 more
doaj   +1 more source

An Abstract Result on Projective Aggregation Functions

Axioms, 2018
A general characterization result of projective aggregation functions is shown, the proof of which makes use of the celebrated Arrow’s theorem, thus providing a link between aggregation functions theory and social choice theory.
Juan C. Candeal
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Interval-valued Pythagorean Fuzzy Frank Power Aggregation Operators based on An Isomorphic Frank Dual Triple

International Journal of Computational Intelligence Systems, 2018
Interval-valued Pythagorean fuzzy sets (PFSs), as an extension of PFSs, have strong potential in the management of complex uncertainty in real-world applications.
Yi Yang, Zhen-Song Chen, Yue-Hua Chen, Kwai-Sang Chin   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source