Results 61 to 70 of about 64,082 (265)

Development of the Theory of Six Value Aggregation Paths in Network Modeling for Spatial Analyses

ISPRS International Journal of Geo-Information, 2020
The dynamic development of spatial structures entails looking for new methods of spatial analysis. The aim of this article is to develop a new theory of space modeling of network structures according to six value aggregation paths: minimum and maximum ...
Anna Maria Kowalczyk, Tomasz Bajerowski
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Graph Learning with Multiplicative Aggregation for Solar Filament Fragment Association Modeling in Full-disk Hα Images

The Astrophysical Journal Supplement Series
Solar filaments are prominent features in H α observations. During their evolution, they often exhibit complex morphological and topological changes, which, due to line-of-sight projection effects, appear as fragmentation and merging.
GaoFei Zhu, GangHua Lin, Xiao Yang, Suo Liu, Yu Liu, ZhiSheng Gao, Cheng Zeng   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A Possible Connection Between Plant Longevity and the Absence of Protein Fibrillation: Basis for Identifying Aggregation Inhibitors in Plants

Frontiers in Plant Science, 2019
The ability of proteins to aggregate to form well-organized β-sheet rich amyloid fibrils is increasingly viewed as a general if regrettable property of the polypeptide chain.
Hossein Mohammad-Beigi, Lars Kjaer, Hoda Eskandari, Farhang Aliakbari, Gunna Christiansen, Gianluca Ruvo, Jane L. Ward, Daniel Erik Otzen, Daniel Erik Otzen   +8 more
doaj   +1 more source

Microfluidic Protein Imaging Platform: Study of Tau Protein Aggregation and Alzheimer’s Drug Response

Bioengineering, 2020
Tau protein aggregation is identified as one of the key phenomena associated with the onset and progression of Alzheimer’s disease. In the present study, we performed on-chip confocal imaging of tau protein aggregation and tau–drug interactions using a ...
Shubha Jain, Sarpras Swain, Lopamudra Das, Sarita Swain, Lopamudra Giri, Anand Kumar Kondapi, Harikrishnan Narayanan Unni   +6 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Application of single-molecule analysis to singularity phenomenon of cells

Biophysics and Physicobiology
Single-molecule imaging in living cells is an effective tool for elucidating the mechanisms of cellular phenomena at the molecular level. However, the analysis was not designed for throughput and requires high expertise, preventing it from reaching large
Michio Hiroshima, Hiroko Bannai, Gen Matsumoto, Masahiro Ueda   +3 more
doaj   +1 more source

Red’s cafè

And, 2020
The ability of physical places to become symbols of sociality and aggregation, belongs to that world of phenomena indefinable by the human sciences, far from any rational theory and made up of uncontrolled variables.
Andrea Parisella, Stefano Di Base
doaj  

Probing Globular Protein Self-Assembling Dynamics by Heterodyne Transient Grating Experiments

Applied Sciences, 2019
In this work, we studied the propagation of ultrasonic waves of lysozyme solutions characterized by different degrees of aggregation and networking. The experimental investigation was performed by means of the transient grating (TG) spectroscopy as a ...
Sara Catalini, Andrea Taschin, Paolo Bartolini, Paolo Foggi, Renato Torre   +4 more
doaj   +1 more source