Results 71 to 80 of about 63,435 (296)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A Possible Connection Between Plant Longevity and the Absence of Protein Fibrillation: Basis for Identifying Aggregation Inhibitors in Plants

Frontiers in Plant Science, 2019
The ability of proteins to aggregate to form well-organized β-sheet rich amyloid fibrils is increasingly viewed as a general if regrettable property of the polypeptide chain.
Hossein Mohammad-Beigi, Lars Kjaer, Hoda Eskandari, Farhang Aliakbari, Gunna Christiansen, Gianluca Ruvo, Jane L. Ward, Daniel Erik Otzen, Daniel Erik Otzen   +8 more
doaj   +1 more source

Microfluidic Protein Imaging Platform: Study of Tau Protein Aggregation and Alzheimer’s Drug Response

Bioengineering, 2020
Tau protein aggregation is identified as one of the key phenomena associated with the onset and progression of Alzheimer’s disease. In the present study, we performed on-chip confocal imaging of tau protein aggregation and tau–drug interactions using a ...
Shubha Jain, Sarpras Swain, Lopamudra Das, Sarita Swain, Lopamudra Giri, Anand Kumar Kondapi, Harikrishnan Narayanan Unni   +6 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Application of single-molecule analysis to singularity phenomenon of cells

Biophysics and Physicobiology
Single-molecule imaging in living cells is an effective tool for elucidating the mechanisms of cellular phenomena at the molecular level. However, the analysis was not designed for throughput and requires high expertise, preventing it from reaching large
Michio Hiroshima, Hiroko Bannai, Gen Matsumoto, Masahiro Ueda   +3 more
doaj   +1 more source

Red’s cafè

And, 2020
The ability of physical places to become symbols of sociality and aggregation, belongs to that world of phenomena indefinable by the human sciences, far from any rational theory and made up of uncontrolled variables.
Andrea Parisella, Stefano Di Base
doaj  

Probing Globular Protein Self-Assembling Dynamics by Heterodyne Transient Grating Experiments

Applied Sciences, 2019
In this work, we studied the propagation of ultrasonic waves of lysozyme solutions characterized by different degrees of aggregation and networking. The experimental investigation was performed by means of the transient grating (TG) spectroscopy as a ...
Sara Catalini, Andrea Taschin, Paolo Bartolini, Paolo Foggi, Renato Torre   +4 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Synthesis and Characterization of Multilayer 3D Chiral Polymers with Enhanced Optical Properties

Molecules
This study reports the synthesis of novel multilayer 3D chiral polymers using 2,2′-(2,7-Naphthalenediyl)bis[4,4,5,5-tetramethyl-1,3,2-dioxaborolane] and 1,8-dibronaphthalene along with its derivatives as key precursors. Comprehensive characterization was
Sai Zhang, Xiaobei Jin, Daixiang Chen, Qingzheng Xu, Tao Wang, Xiuyuan Qin, Jialing Mao, Yue Zhang, Shenghu Yan, Guigen Li   +9 more
doaj   +1 more source