Results 71 to 80 of about 266,965 (294)

Leibnizian Bodies: Phenomena, Aggregates of Monads, or Both? [PDF]

, 2016
I propose a straightforward reconciliation of Leibniz’s conception of bodies as aggregates of simple substances (i.e., monads) with his doctrine that bodies are the phenomena of perceivers, without in the process saddling him with any equivocations.
Puryear, Stephen
core  

Renormalisation-theoretic analysis of non-equilibrium phase transitions I: The Becker-Doring equations with power law rate coefficients

, 2001
We study in detail the application of renormalisation theory to models of cluster aggregation and fragmentation of relevance to nucleation and growth processes.
Amit D J, Blackman J A, Bricmont J, Bricmont J, Brilliantov N V, Cardy J, Carr J, Carr J, Coveney P V, Coveney P V, Coveney P V, Coveney P V, Goldenfeld N, HendriksE M, Itzykson C, Jonathan A D Wattis, Krapivsky P L, Krapivsky P L, Peliti L, Penrose O, Peter V Coveney, Samsel R W, van Dongen P G J, van Dongen P G J, Velazquez J J L, Wattis J A D, Wattis J A D, Wattis J A D, Wattis J A D, Wattis J A D, Woodruff S L, Woodruff S L, Woodruff S L   +32 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Microfluidic Protein Imaging Platform: Study of Tau Protein Aggregation and Alzheimer’s Drug Response

Bioengineering, 2020
Tau protein aggregation is identified as one of the key phenomena associated with the onset and progression of Alzheimer’s disease. In the present study, we performed on-chip confocal imaging of tau protein aggregation and tau–drug interactions using a ...
Shubha Jain, Sarpras Swain, Lopamudra Das, Sarita Swain, Lopamudra Giri, Anand Kumar Kondapi, Harikrishnan Narayanan Unni   +6 more
doaj   +1 more source

(WP 2015-03) Lawson on Veblen on Social Ontology [PDF]

, 2015
This paper discusses Lawson’s use of Veblen’s concept of ‘neoclassical economics’ and argument that the category of neoclassical economics should be jettisoned on the grounds that it obfuscates effective critique of mainstream economics.
Davis, John B.
core   +1 more source

Aggregation of magnetic holes in a rotating magnetic field

, 2008
We have experimentally investigated field induced aggregation of nonmagnetic particles confined in a magnetic fluid layer when rotating magnetic fields were applied.
Geir Helgesen, Jozef Černák, T. Vicsek
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

A Possible Connection Between Plant Longevity and the Absence of Protein Fibrillation: Basis for Identifying Aggregation Inhibitors in Plants

Frontiers in Plant Science, 2019
The ability of proteins to aggregate to form well-organized β-sheet rich amyloid fibrils is increasingly viewed as a general if regrettable property of the polypeptide chain.
Hossein Mohammad-Beigi, Lars Kjaer, Hoda Eskandari, Farhang Aliakbari, Gunna Christiansen, Gianluca Ruvo, Jane L. Ward, Daniel Erik Otzen, Daniel Erik Otzen   +8 more
doaj   +1 more source

Development of the Theory of Six Value Aggregation Paths in Network Modeling for Spatial Analyses

ISPRS International Journal of Geo-Information, 2020
The dynamic development of spatial structures entails looking for new methods of spatial analysis. The aim of this article is to develop a new theory of space modeling of network structures according to six value aggregation paths: minimum and maximum ...
Anna Maria Kowalczyk, Tomasz Bajerowski
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source