Results 121 to 130 of about 401,541 (313)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Reschedule of Distributed Energy Resources by an Aggregator for Market Participation
Energies, 2018 Demand response aggregators have been developed and implemented all through the world with more seen in Europe and the United States. The participation of aggregators in energy markets improves the access of small-size resources to these, which enables ...
Pedro Faria, João Spínola, Zita Vale
doaj +1 more source
Philosophy & Public Affairs, 2017 Consider the following pair of cases: \ud \ud Case 1. You can save one person from death, or some larger number of people, N 1, from paralysis. \ud \ud Case 2.You can save one person from death, or some larger number of people, N 2, from a mild headache.
openaire +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Methods for Aggregation and Remuneration of Distributed Energy Resources
Applied Sciences, 2018 Distributed energy resource integration in power systems has advantages and challenges in both the economic and the technical operation of the system. An aggregator, as in the case of a Virtual Power Player, is essential in order to support the operation
Pedro Faria, João Spínola, Zita Vale
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
IEEE AccessThe increase in EV (Electric Vehicle) charging demands significantly affects the power system; thus, developing an optimal operating system is necessary to improve the power system stability while considering the transportation network.
Myeongseok Chae, Taesic Kim, Dongjun Won
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source