Results 111 to 120 of about 220,822 (315)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Acute Interventions for Aggression and agitation in psychosiS (AIAS): Study protocol for a systematic review and network meta-analysis

, 2019
Introduction Individuals with psychosis may access emergency services due to aggression and agitation. When the de-escalation technique fails to achieve tranquillisation, several pharmacological options are available.
Toshi A Furukawa, Salanti, Georgia, Shokraneh, Farhad, D'Agostino, Armando, Furukawa T. A., D'Agostino A., Farhad Shokraneh, Salanti G., D�Agostino, Armando, D’Agostino, Armando, Ostinelli E. G., Ostinelli, Edoardo G, Ostinelli, Edoardo G., Georgia Salanti, Furukawa, Toshi A., Armando D’Agostino, Edoardo G Ostinelli, Furukawa, Toshi A, Shokraneh F.   +18 more
core   +1 more source

From Hitting to Tattling to Gossip: An Evolutionary Rationale for the Development of Indirect Aggression

Evolutionary Psychology, 2014
Adult humans are characterized by low rates of intra-group physical aggression. Since children tend to be more physically aggressive, an evolutionary developmental account shows promise for explaining how physical aggression is suppressed in adults.
Gordon P. D. Ingram
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Libido, aggression and aggressiveness

, 1993
Referat, predstavljen na prvem Vzhodnoevropskem psihoanalitičnem seminarju,na Dunaju, (april 1993) predstavlja pregled zadnjih sprememb v psihoanalitičnem konceptu agresije. Zavzema se za doslednejšo rabo pojmov agresije in agresivnosti - prvega za destruktivne pojave in oblike, drugega za označevanje gonskih silnic, agresivnih teženj, ki se kažejo kot
openaire   +2 more sources

PREVENTING AGGRESSION IN YOUTH: A SOCIAL ASPECT

Неперервна професійна освіта: теорія та практика, 2020
The article deals with the phenomenon of aggression as a social phenomenon that has both social and biological (psychological) conditions. Based on the analysis of scientific sources the author has classified the types of aggression, emphasizing that the
Maria Сhmielewska
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Initial Validation of a Brief Pictorial Measure of Caregiver Aggression: The Family Aggression Screening Tool

, 2016
In the present study, we report on the development and initial psychometric properties of the Family Aggression Screening Tool (FAST). The FAST is a brief, self-report tool that makes use of pictorial representations to assess experiences of caregiver ...
Viding, E, Holden, GW, McCrory, EJ, Cecil, CAM, Barker, ED   +4 more
core  

Individual cognitive-behavioural anger treatment for people with mild-borderline intellectual disabilities and histories of aggression: a controlled trial

, 2005
Objectives - Anger is a significant predictor and activator of violent behaviour in patients living in institutional settings. There is some evidence for the value of cognitive-behavioural treatments for anger problems with people with intellectual ...
Thorne, Ian, John L. Taylor, Raymond W. Novaco, Ian Thorne, Gillmer, Bruce, Bruce T. Gillmer, Taylor, John, Novaco, Raymond, Alison Robertson, Robertson, Alison   +9 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source