Results 91 to 100 of about 126,515 (248)

Effect of Spiritual Health and Resilience on Aggressiveness in a Sample of Active Christian Young Adults

Actualidades en Psicología
Objective. This study evaluated the adequacy of a structural equation model examining the relationship between spiritual health, resilience, and aggressiveness. Method.
Ruth Priscila Badilla Torres, Carlos Marcelo Moroni, Zandra Covarrubias, Raúl Rodríguez   +3 more
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Psychological aspects of aggression among police personnel

Bulletin of Kharkiv National University of Internal Affairs
The article presents psychological aspects of aggression in the context of professional activity of police personnel. The nature and manifestations of aggression in the working environment of police officers are investigated, the factors that cause ...
Yа. S. Ponomarenko
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Reduced expression of FOXE1 in differentiated thyroid cancer, the contribution of CPG methylation, and their clinical relevance

Frontiers in Endocrinology
IntroductionForkhead box E1 (FOXE1) is a transcription factor with a crucial role in thyroid morphogenesis and differentiation. Promoter hypermethylation downregulates FOXE1 expression in different tumor types; nevertheless, its expression and ...
Erika Urbano De Lima, Filipe Ferreira Dos Santos, Filipe Ferreira Dos Santos, Igor Campos Da Silva, Cláudio Rogério Alves De Lima, Vitoria Sousa Frutuoso, Gustavo Felisola Caso, Paloma Ramos De Oliveira, Ana Karina Bezerra, Janete Maria Cerutti, Rodrigo Esaki Tamura, Rodrigo Esaki Tamura, Helton Estrela Ramos, Ileana Gabriela Sanchez de Rubio, Ileana Gabriela Sanchez de Rubio   +14 more
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

“Secreted in Xylem” Genes (SIX Genes): Relationship to the Aggressiveness of Fusarium oxysporum f. sp. albedinis

Plants
Fusarium oxysporum f. sp. Albedinis (Foa) is the causal agent of Bayoud disease, responsible for the loss of 75% of date palm trees in Morocco and posing a threat to its cultivation across North Africa.
Abdelhi Dihazi, Youness Jouihri, Ahmed Tadlaoui-Ouafi, Mohamed Najib Alfeddy, Cherkaoui El Modafar, Hassan Dihazi, Abdellatif El Meziane, Mohammad Sayari, Fouad Daayf   +8 more
doaj   +1 more source

Aggressive leaders

The RAND Journal of Economics, 2006
I characterize the incentives to undertake strategic investments in markets with Nash competition and endogenous entry. Contrary to the case with an exogenous number of firms, when the investment increases marginal profitability, only a “top dog” strategy is optimal.
openaire   +3 more sources