Results 71 to 80 of about 322,361 (305)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Competing Species Dynamics: Qualitative Advantage versus Geography

, 1998
A simple cellular automata model for a two-group war over the same territory is presented. It is shown that a qualitative advantage is not enough for a minority to win.
Chopard, Bastien, Droz, Michel, Galam, Serge, Masselot, Alexander   +3 more
core   +2 more sources

Personality traits and beliefs about peers\u2019 on-road behaviors as predictors of adolescents\u2019 moped-riding profiles. [PDF]

, 2018
Several efforts aimed at discriminating between different degrees of on-road risky attitudes have been devoted to the identification of personality profiles among young drivers.
Gianfranchi, Evelyn, Tagliabue, Mariaelena, Vidotto, Giulio   +2 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Ki-67 Labelling Index as a Predictor of Invasive Features in Thyroid Cancer: Retrospective Analysis and Implications

Current Oncology
Background: Ki-67 immunostaining is commonly used in neuroendocrine tumors to estimate the proliferative index and for grading. This study investigates its association with the invasiveness of follicular-derived thyroid carcinomas (TCs).
Raisa Chowdhury, Raihanah Alsayegh, Véronique-Isabelle Forest, Marc Philippe Pusztaszeri, Sabrina Daniela da Silva, Livia Florianova, Richard J. Payne   +6 more
doaj   +1 more source

How do you say ‘hello’? Personality impressions from brief novel voices [PDF]

, 2014
On hearing a novel voice, listeners readily form personality impressions of that speaker. Accurate or not, these impressions are known to affect subsequent interactions; yet the underlying psychological and acoustical bases remain poorly understood ...
A Todorov, A Todorov, AC Little, AC Little, AC Little, Alexander Todorov, AW Young, B Yao, B Yao, BC Jones, C Ferdenzi, C Nass, CA Klofstad, CA Sutherland, CC Tigue, CD Aronovitch, Charles R. Larson, CL Apicella, CL Apicella, CP Said, CT Ferrand, CY Olivola, D Rendall, DA Kenny, DA Leopold, DA Puts, DC Funder, DR Feinberg, DR Feinberg, DS Berry, DS Berry, DS Berry, DS Berry, E Vannoni, FT Passini, G Rhodes, G Rhodes, GW Allport, IR Titze, IS Penton-Voak, J Kreiman, J Willis, JH Langlois, JH Langlois, JJ Horton, JJ Ohala, JM Montepare, JS Wiggins, JW Lewis, K Grammer, K Miyake, KR Scherer, L Bruckert, L Bruckert, L Germine, LA Zebrowitz, LA Zebrowitz, LA Zebrowitz, LA Zebrowitz, LA Zebrowitz-McArthur, LZ McArthur, M Latinus, M Latinus, M Latinus, M Shevlin, M Zuckerman, M Zuckerman, M Zuckerman, NJ Lass, NJ Lass, NN Oosterhof, O Baumann, P Belin, P Belin, P Boersma, P Borkenau, Pascal Belin, PE Bestelmeyer, PEG Bestelmeyer, Phil McAleer, R Hassin, RA Page, RM Krauss, RR Mccrae, RS Kramer, S Evans, S Patel, S Rosenberg, SA Collins, SC Verosky, SJ Ko, SM Hughes, SM Hughes, SM Hughes, ST Fiske, TK Perrachione, V Bruce, V Pivonkova, VX Luevano, WA van Dommelen, WA van Dommelen, WT Fitch, WT Fitch, WT Norman   +103 more
core   +5 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Formation of the phenotypic structure of Phytophthora infestans population in Poland during 1987-2001

Acta Agrobotanica, 2013
The formation of phenotypic structure of P.infestans population in Poland was determined by analyzing 1603 isolates collected from 1987 to 2001. The race complexity, low at the beginning of experiment, has been increasing from year to year and reached ...
Hanna Zarzycka, Sylwester Sobkowiak, Renata Lebecka, Beata Tatarowska   +3 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A Rat Model of Human Behavior Provides Evidence of Natural Selection Against Underexpression of Aggressiveness-Related Genes in Humans

Frontiers in Genetics, 2019
Aggressiveness is a hereditary behavioral pattern that forms a social hierarchy and affects the individual social rank and accordingly quality and duration of life. Thus, genome-wide studies of human aggressiveness are important.
Dmitry Oshchepkov, Mikhail Ponomarenko, Mikhail Ponomarenko, Natalya Klimova, Irina Chadaeva, Irina Chadaeva, Anatoly Bragin, Ekaterina Sharypova, Ekaterina Sharypova, Svetlana Shikhevich, Rimma Kozhemyakina, Rimma Kozhemyakina   +11 more
doaj   +1 more source