Results 91 to 100 of about 231,360 (291)

Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing

open access: yesAdvanced Science, EarlyView.
CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen   +15 more
wiley   +1 more source

Управління міжнародним бізнесом: Agility Journey для високотехнологічних компаній [PDF]

open access: yes, 2019
The purpose of the article is the development of recommendations for the business maturity determination and measurement in the implementation of the agile approach for high-tech companies.
Rusanova, L. D.   +1 more
core  

Biomimetic Multiscale‐Structured Biomass Graphene/Polyurethane Sponge Composite for Flexible Pressure Sensors and Intelligent Cushioning Materials

open access: yesAdvanced Science, EarlyView.
In this study, a multifunctional conductive sponge composite (MAPU) is developed using a biomimetic, hierarchical construction strategy emulating the growth process of natural wood. This approach involved integrating biomass‐derived graphitic nanoflakes, synthesized from luffa vine (LVGN), into a polyurethane (PU) sponge matrix.
Runmin Xu   +9 more
wiley   +1 more source

Technologies and infrastructure: costs and obstacles in developing large-scale computer–based testing

open access: yesEducation Inquiry, 2019
This paper identifies important technological, financial, and equity challenges to the development and implementation of online or onscreen educational testing. The insights are based on the author’s experiences in New Zealand of being the senior project
Gavin T. L. Brown
doaj   +1 more source

Dead Matter, Living Machines: Repurposing Crustaceans' Abdomen Exoskeleton for Bio‐Hybrid Robots

open access: yesAdvanced Science, EarlyView.
Crustacean exoskeletons, repurposed from food waste, are engineered into sustainable bending actuators combining biotic structure with synthetic control. The augmented exoskeletons achieve rapid and robust motion with lightweight body and can be used as part of robotic manipulators, grippers and swimmers.
Sareum Kim, Kieran Gilday, Josie Hughes
wiley   +1 more source

Factors Affecting Agile Software Project Success

open access: yesIEEE Access
Uncertainties and changes in software requirements have compelled companies to become more agile in software development projects. To keep pace with the agile environment, companies incorporate agile software development methodologies into their projects.
Burcu Binboga, Cigdem Altin Gumussoy
doaj   +1 more source

Calculating Completeness of Agile Scope in Scaled Agile Development

open access: yesIEEE Access, 2018
Flexible nature of scope definition in agile makes it difficult or impossible to measure its completeness and quality. The aim of this paper is to highlight the important ingredients of scope definition for agile projects and to present a method for ...
Sunnia Amjad   +6 more
doaj   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

open access: yesAdvanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu   +7 more
wiley   +1 more source

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