Results 91 to 100 of about 231,360 (291)
Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing
Advanced Science, EarlyView.CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen +15 more
wiley +1 more source
Adapting agile development practices for hyper-agile environments: lessons learned from a COVID-19 emergency response research project. [PDF]
Inf Technol Manag, 2022 Nazir S, Price B, Surendra NC, Kopp K.
europepmc +1 more source
Управління міжнародним бізнесом: Agility Journey для високотехнологічних компаній [PDF]
, 2019 The purpose of the article is the development of recommendations for the business maturity determination and measurement in the implementation of the agile approach for high-tech companies.
Rusanova, L. D. +1 more
core
Advanced Science, EarlyView.In this study, a multifunctional conductive sponge composite (MAPU) is developed using a biomimetic, hierarchical construction strategy emulating the growth process of natural wood. This approach involved integrating biomass‐derived graphitic nanoflakes, synthesized from luffa vine (LVGN), into a polyurethane (PU) sponge matrix.
Runmin Xu +9 more
wiley +1 more source
Education Inquiry, 2019 This paper identifies important technological, financial, and equity challenges to the development and implementation of online or onscreen educational testing. The insights are based on the author’s experiences in New Zealand of being the senior project
Gavin T. L. Brown
doaj +1 more source
Dead Matter, Living Machines: Repurposing Crustaceans' Abdomen Exoskeleton for Bio‐Hybrid Robots
Advanced Science, EarlyView.Crustacean exoskeletons, repurposed from food waste, are engineered into sustainable bending actuators combining biotic structure with synthetic control. The augmented exoskeletons achieve rapid and robust motion with lightweight body and can be used as part of robotic manipulators, grippers and swimmers.
Sareum Kim, Kieran Gilday, Josie Hughes
wiley +1 more source
Factors Affecting Agile Software Project Success
IEEE AccessUncertainties and changes in software requirements have compelled companies to become more agile in software development projects. To keep pace with the agile environment, companies incorporate agile software development methodologies into their projects.
Burcu Binboga, Cigdem Altin Gumussoy
doaj +1 more source
Calculating Completeness of Agile Scope in Scaled Agile Development
IEEE Access, 2018 Flexible nature of scope definition in agile makes it difficult or impossible to measure its completeness and quality. The aim of this paper is to highlight the important ingredients of scope definition for agile projects and to present a method for ...
Sunnia Amjad +6 more
doaj +1 more source
Advanced Science, EarlyView.Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu +7 more
wiley +1 more source