Results 101 to 110 of about 12,043,072 (290)

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

Advanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen, Zhiquan Liu, Wenmin Wang, Qing Wang, Tia J. Kowal, Fan Zhang, Grzegorz Walkiewicz, Faruk Hossen, Herbert M. Lachman, Jinqiong Zhou, Yiting Wang, Yang Sun   +11 more
wiley   +1 more source

Facilitators and inhibitors for the adoption of agile methods

, 2010
This paper examines factors which facilitate or inhibit the adoption of agile methods in an organization. The paper presents an overview of agile methodologies and the key features of the agile corporation, exploring the synergistic relationship they ...
Koronios, Andy, Van Der Vyver, Glen, Lane, Michael   +2 more
core   +1 more source

Cross‐scale Material‐Structure Synergy for 2D Metamaterials: Toward Customizable Intelligent Electromagnetic Manipulation in Multiphysics Fields

Advanced Science, EarlyView.
Recent advances in metasurface‐enabled low‐observable technologies are reviewed from the perspective of cross‐scale material–structure synergy. Electromagnetic, thermal, optical, and acoustic stealth are highlighted together with dynamic tuning, programmable coding, data‐driven inverse design, artificial intelligence, multispectral compatibility, and ...
Shuhao Wang, Xing Yang, Liping Liu, Yang Peng, Yangyang Wang, Hualiang Lv   +5 more
wiley   +1 more source

Agile methods in software engineering education

, 2022
S.284-293 : Ill., Lit.Agile methods such as extreme programming (XP) are becoming increasingly important for the rapid development of software applications. However, there is a tradeoff in using agile methods.
Bunse, C., Feldmann, R.L., Doerr, J.
core   +1 more source

Project-based approach to teaching students new product development skills

Вестник университета
The purpose of the study is to analyze learning experience of management students and new product development teams management. The list of skills that are necessary to use flexible development methods has been reviewed.
A. A. Gusakov
doaj   +1 more source

Arthropod‐Inspired Miniature Modular Vibration Direct‐Drive Robot With Untethered Locomotion

Advanced Science, EarlyView.
This work presents an arthropod‐inspired untethered miniature modular vibration direct‐drive robot. By utilizing standardized driving units and nested locking interfaces, on‐demand reconfiguration into quadruped, hexapod, octopod, and circular morphologies is achieved.
Shijing Zhang, Ziteng Liu, Youwei Liu, Dehong Wang, Yingxiang Liu   +4 more
wiley   +1 more source

Agile Game: A Project Management Game for Agile Methods

Since mid-1990s, companies have adopted agile methods and incorporated them in their development methodologies. For this reason, future project managers and developers need to have a full understanding of these methods.
Gkritsi, Aikaterini
core   +1 more source

Closing the Loop: High‐Precision 3D Photofabrication in Living Tissues

Advanced Science, EarlyView.
Writing 3D microstructures inside living tissue demands more than laser access; It demands information. Hierarchical sensing captures thermal and mechanical states across pulse‐train, voxel, and structure timescales, feeding a controller that steers the laser in real time.
Amirbahador Zeynali, Mangirdas Malinauskas, Giuseppe Chirico   +2 more
wiley   +1 more source

Weaving Agility in Safety-Critical Software Development for Aerospace: From Concerns to Opportunities

IEEE Access
Domain-specific standards and documents heavily regulate safety-critical systems. One example is the DO-178C standard for aerospace, which guides organizations to achieve system safety and evidence for their certification.
J. Eduardo Ferreira Ribeiro, Joao Gabriel Silva, Ademar Aguiar   +2 more
doaj   +1 more source